...Shouhong Xuan; Lori Sussel GATA4 and GATA6 are zinc finger transcription factors that have important functions in several mesodermal and endodermal organs, including heart, liver and pancreas. In humans, heterozygous mutations of either factor are associated with pancreatic agenesis; however...

...-implantation embryo, but later marks the PrE. Moreover, the addition of LIF to cultured embryos increases the GATA6 + PrE population, whereas inhibition of JAK/STAT signalling reduces both NANOG + epiblast and GATA6 + PrE. The reduction of the NANOG + Epi might be explained by its precocious differentiation...

... that engagement of PRC1 at target genes is Oct3/4-dependent,whereas engagement of Oct3/4 is PRC1-independent. Moreover, upon differentiation induced by Gata6 expression, most of the Ring1A/B target genes are derepressed and the binding of Ring1A/B to their target loci is also decreased. Collectively...

... that endoderm differentiation and endoderm-specific gene expression, such as expression of laminin 1 subunits, is controlled by GATA6 induced by FGF. Subsequently,differentiation of the non-polar primitive ectoderm into columnar epithelium of the epiblast is induced by laminin 1. Using GATA6 transformed Lamc1...

...Honghua Yang; Min Min Lu; Lili Zhang; Jeffrey A. Whitsett; Edward E. Morrisey GATA6 is a member of the GATA family of zinc-finger transcriptional regulators and is the only known GATA factor expressed in the distal epithelium of the lung during development. To define the role that GATA6 plays...

...Richard Keijzer; Minke van Tuyl; Carel Meijers; Martin Post; Dick Tibboel; Frank Grosveld; Manoussos Koutsourakis Recent loss-of-function studies in mice show that the transcription factor GATA6 is important for visceral endoderm differentiation. It is also expressed in early bronchial epithelium...