... - and gata3 -dependent precursors co-expressing markers of V2b and V2s interneurons. Chemical blockage of Notch signalling causes a decrease in V2s and an increase in V2b cells. Our results are consistent with the existence of at least two types of precursor arranged in a hierarchical manner in the V2 domain...

... development. In early mammalian embryos, GATA3 is selectively expressed in the extraembryonic trophoblast lineage and regulates gene expression to promote trophoblast fate. However, trophoblast-specific GATA3 function is dispensable for early mammalian development. Here, using dual conditional knockout mice...

... expressing vesicular glutamate transporter 3 ( Vglut3 ) or serotonin transporter ( Sert ). These populations differ in their requirements for transcription factors Gata2 and Gata3, which are activated in the post-mitotic precursors. Gata2 operates upstream of Gata3 as a cell fate selector in both populations...

... and Gata3 control the balance between the generation of inhibitory and excitatory neurons. In the absence of Tal1, or both Gata2 and Gata3, the GABAergic precursors adopt glutamatergic fates and populate the glutamatergic nuclei in excessive numbers. Together, our results uncover developmental regulatory...

... and that depends on Ret signaling. Analysis of Ret mutant mice at birth reveals hydronephrosis and defective ureter maturation, abnormalities that our results suggest are caused, at least in part, by delayed insertion of the ND. We find a similar set of malformations in mutants lacking either Gata3 or Raldh2. We...

...Gina M. Bernardo; Kristen L. Lozada; John D. Miedler; Gwyndolen Harburg; Sylvia C. Hewitt; Jonathan D. Mosley; Andrew K. Godwin; Kenneth S. Korach; Jane E. Visvader; Klaus H. Kaestner; Fadi W. Abdul-Karim; Monica M. Montano; Ruth A. Keri FOXA1, estrogen receptor α (ERα) and GATA3 independently...

...Dorota Kurek; George A. Garinis; J. Hikke van Doorninck; Jacqueline van der Wees; Frank G. Grosveld The transcription factor Gata3 is crucially involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, what...

...Takashi Moriguchi; Nakano Takako; Michito Hamada; Atsuko Maeda; Yuki Fujioka; Takashi Kuroha; Reuben E. Huber; Susan L. Hasegawa; Arvind Rao; Masayuki Yamamoto; Satoru Takahashi; Kim-Chew Lim; James Douglas Engel Gata3 mutant mice expire of noradrenergic deficiency by embryonic day (E) 11 and can...

... microarray screen for genes specifically expressed in the pro/mesonephros and regulated by Pax proteins, we identified Gata3 , a transcription factor gene associated with hypoparathyroidism, deafness and renal anomaly (HDR) syndrome. Gata3 is already expressed in the pronephric anlage, together with Pax2...

..., which includes Mash1, Phox2b, Hand2 and Phox2a. Here, we have studied the function of Gata2 and Gata3 zinc-finger transcription factors in autonomic neuron development. In the chick, Gata2 but not Gata3 is expressed in developing sympathetic precursor cells. Gata2 expression starts after Mash1, Phox2b...

... and its derivatives causes arrest of tooth morphogenesis and lack of external hair. The hair shaft and hair follicle inner root sheath (IRS) fail to differentiate, and expression of the known transcriptional regulators of follicular differentiation Msx1,Msx2, Foxn1 and Gata3 is markedly downregulated...

... for the activation of Fgf3 expression and the maintenance of Fgf10 and Bmp4 expression in the otic vesicle. Furthermore, loss of Six1 function alters the expression pattern of Nkx5.1 and Gata3 , indicating that Six1 is required for regional specification of the otic vesicle. Finally, our data suggest...

...Illar Pata; Michèle Studer; J. Hikke van Doorninck; James Briscoe; Sulev Kuuse; J. Douglas Engel; Frank Grosveld; Alar Karis In this paper, we show that the transcription factor GATA3 is dynamically expressed during hindbrain development. Function of GATA3 in ventral rhombomere (r) 4 is dependent...