...Gina Broitman-Maduro; Simo Sun; Taisei Kikuchi; Morris F. Maduro ABSTRACT Endoderm specification in Caenorhabditis elegans occurs through a network in which maternally provided SKN-1/Nrf, with additional input from POP-1/TCF, activates the GATA factor cascade MED-1,2→END-1,3→ELT-2,7. Orthologues...

... of tissues derived from all three germ layers, including the skin, brain, gonads, liver, hematopoietic, cardiovascular and urogenital systems. The crucial activity of GATA factors is underscored by the fact that inactivating mutations in most GATA members lead to embryonic lethality in mouse models...

... explants blocks induction of hedgehog-dependent gene expression. We demonstrate that GATA factors can interact with Gli factors and can recruit the transcriptional co-factor FOG1 (ZFPM1) to the regulatory region of the mouse Gli1 gene, repressing the induction of Gli1 by SHH by binding to both GATA and Gli...

... ( [email protected] ; [email protected] ) Competing interests statement The authors declare no competing financial interests. 12 8 2012 © 2012. 2012 Embryonic polarity GATA factors Chick embryo Gastrulation Primitive streak formation Nodal Vg1 Gdf-1 Embryonic regulation...

...,and for the origins of stem cells in the adult heart. * Author for correspondence (e-mail: [email protected] ) 24 2 2009 © 2009. 2009 Myelopoiesis Cardiogenesis GATA factors Second heart field Haemangioblasts Transcriptional regulation Evolution Adult stem cells Zebrafish...

...Boni Anatole Afouda; Aldo Ciau-Uitz; Roger Patient The individual contributions of the three vertebrate GATA factors to endoderm formation have been unclear. Here we detail the early expression of GATA4, 5 and 6 in presumptive endoderm in Xenopus embryos and their induction of endodermal markers...

.... 2003 Drosophila Heart Cardiogenesis Mesoderm pannier u-shaped tinman dpp Gata factors In Drosophila , bilaterally symmetric heart progenitors are specified within the dorsal most region of the mesoderm. These progenitor cells then migrate to the dorsal midline where...

... . *Author for correspondence (e-mail: [email protected] ) 7 9 2001 © 2001. 2001 Pnr GATA factors Selector genes DV body axis Dpp Dorsal closure Drosophila By contrast, relatively little is known about genetic subdivisions of the body in the DV axis. A crucial event...

... of serpent in fat-cell specification and in cell fate choices. * Author for correspondence (e-mail: [email protected] ) 13 March 2001 12 January 2001 © 2001 by Company of Biologists 2001 Mesoderm Cell fate Fat cells GATA factors Drosophila melanogaster During...

... in ventral mesendoderm during gastrulation and are required for the differentiation of blood and endodermal tissues. Injection ventrally of a dominantinterfering GATA factor (called G2en) induced the formation of secondary axes that phenocopy those induced by the dominant-negative BMP receptor. However...

... program, GATA-4 may be the nuclear target of inductive and/or survival factors for precardiac cells. * Author for correspondence (e-mail: [email protected] ) 12 03 1997 © 1997 by Company of Biologists 1997 GATA factors apoptosis heart embryonic stem cells myocyte...

... is the predominant GATA factor, are blocked at a relatively early stage of maturation. * Author for correspondence † Present address: National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK ‡ Present address: Department of Medicine, Section of Cardiology, University...

... a factor that is quite similar to mammalian GATA factors. The dGATAa protein sequence contains the two zinc finger DNA-binding domain of the GATA class but bears no additional sequence similarity to any of the vertebrate GATA factors. Analysis of dGATAa gene transcription during Drosophila development...