...T. Michael Creed; Rajkumar Baldeosingh; Christian L. Eberly; Caroline S. Schlee; MinJung Kim; Jevon A. Cutler; Akhilesh Pandey; Curt I. Civin; Nancy G. Fossett; Tami J. Kingsbury ABSTRACT The GATA and PAX-SIX-EYA-DACH transcriptional networks (PSEDNs) are essential for proper development across...

... at the 32-cell stage. β-Catenin Ciona intestinalis Gata Zic Ascidian Germ layer formation Ministry of Education, Culture, Sports, Science, and Technology 10.13039/501100001700 Japan Society for the Promotion of Science 10.13039/501100001691 26711014 25118510...

... poorly understood. One such code defined by the homeodomain transcription factor Even-skipped (Eve) and by the GATA 2/3 homologue Grain (Grn) is specifically required for motor axon projection towards dorsal muscles in Drosophila . Using different mutant combinations, we present genetic evidence...

... endoderm Extra-embryonic endoderm Embryonic stem (ES) cell XEN cell PDGF signaling GATA During early mammalian development, two extra-embryonic lineages, trophectoderm (TE) and primitive endoderm (PrE), are specified and segregated away from the pluripotent epiblast (EPI). Extra...

... . Dev. Biol. 119 , 520 - 531 . Fujikura J. , Yamato E. , Yonemura S. , Hosoda K. , Masui S. , Nakao K. , Miyazaki Ji. J. , Niwa H. ( 2002 ). Differentiation of embryonic stem cells is induced by GATA factors . Genes Dev. 16 , 784 - 789...

.../β-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides β-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression...

... and was thought only to regulate the differentiation of a single cell type (pstO). The results presented here challenge this idea. In a novel genetic selection to isolate genes required for DIF signal transduction, we found a mutant( dimC - ) that is a hypomorphic allele of a GATA family transcription factor...

... transcriptional effector LAG-1/CSL that are essential for expression, a non-CSL site required for mesodermal expression, and four predicted binding sites for GATA transcription factors that are required for endodermal expression. We show that endodermal expression involves the GATA transcription factor ELT-2...

... only. Whereas the enhancers of both genes contain critical and interchangeable GATA sites, their distinct patterns of activation stem from the additional presence of two Ets sites in the Ci-otx enhancer. Initially characterized as activating elements in the neural lineages, these Ets sites additionally...

...., Poh, A. and Yamada, T. ( 2002 ). GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord. Dev. Biol. 249 , 30 -43. Kiehn, O. ( 2006 ). Locomotor circuits in the mammalian spinal cord. Annu. Rev. Neurosci. 29 , 279 -306. Kimura, Y., Okamura, Y...

...Yuzhen Zhang; Nibedita Rath; Sridhar Hannenhalli; Zhishan Wang; Thomas Cappola; Shioko Kimura; Elena Atochina-Vasserman; Min Min Lu; Michael F. Beers; Edward E. Morrisey In vitro studies have suggested that members of the GATA and Nkx transcription factor families physically interact...

... network. * Authors for correspondence (e-mail: [email protected] ; [email protected] ) 13 3 2006 © 2006. 2006 Endoderm Development Xenopus Nodal Sox17 Gata Mixer Microarray Gene regulatory network Recent work in Xenopus , zebrafish...

...Anabel Rojas; Sarah De Val; Analeah B. Heidt; Shan-Mei Xu; James Bristow; Brian L. Black The GATA family of zinc-finger transcription factors plays key roles in the specification and differentiation of multiple cell types during development. GATA4 is an early regulator of gene expression during...

... region reflects both the induction of GATA genes by BMP signals, as well as modulation of the transcriptional activity of YY1 by direct interaction of this transcription factor with BMP-activated SMADs. * Author for correspondence (e-mail: [email protected] ) 8 7 2004 ©...

... , 3009 -3020. Jiang, Y. and Evans, T. ( 1996 ). The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev. Biol. 15 , 258 -270. Jones, C. M., Kuehn, M. R., Hogan, B. L. M., Smith, J. C. and Wright, C. V. E...

... ventral inducers. * Author for correspondence (e-mail: [email protected] ) 9 12 2003 © 2004. 2004 Gata Serotonergic neurons Sonic hedgehog During development distinct classes of neurons are specified at stereotypic positions along the dorsoventral and rostrocaudal axes...

... expression causes major morphogenetic movements, resulting in the invagination of the posterior segments into the embryo. This is the first gene that has been shown to affect epithelial morphogenesis by controlling cell rearrangements, and suggests a novel function for GATA transcription factors...

... the expression of the endodermal transcription factors HNF3 and GATA4, nor these factors’ ability to engage target sites in chromatin. We have now found that at 13.5 d, the mesoderm gains a second inhibitory activity, resulting in the irreversible loss of expression of HNF3 (Foxa2) and GATA factors...

...Anne E. Deconinck; Paul E. Mead; Sergei G. Tevosian; John D. Crispino; Samuel G. Katz; Leonard I. Zon; Stuart H. Orkin ABSTRACT Members of the GATA family of zinc-finger transcription factors have critical roles in a variety of cell types. GATA-1, GATA-2 and GATA-3 are required for proliferation...

... GATA Embryonic Lethality Extraembryonic Endoderm Mouse The GATA zinc finger transcription factors play a crucial role in the development and differentiation of a number of tissues. These factors bind the basic consensus sequence A/TGATA/G through a conserved Cys-X 2 -Cys-X 17 -Cys-X 2 -Cys...