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Keywords: Gas1
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Journal Articles
Journal: Development
Development (2020) 147 (23): dev189076.
Published: 14 December 2020
...Martha L. Echevarría-Andino; Benjamin L. Allen ABSTRACT The Hedgehog (HH) pathway controls multiple aspects of craniofacial development. HH ligands signal through the canonical receptor PTCH1, and three co-receptors: GAS1, CDON and BOC. Together, these co-receptors are required during embryogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 897–903.
Published: 15 March 2009
... is specific to loss of polaris activity in the mesenchyme since loss of Polaris in the epithelium has no detrimental affect on tooth development. To further confirm that upregulation of Shh activity is responsible for the ectopic tooth formation, we analysed mice mutant for Gas1 , a Shh protein antagonist...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (12): 2875–2885.
Published: 15 June 2004
... to downregulate Ptc1 in tooth explants, and for isolated diastema mesenchyme to express Ptc1 . A candidate inhibitor in diastema mesenchyme is the glycosylphosphatidylinositol-linked membrane glycoprotein Gas1. Gas1 is normally expressed throughout mandibular arch mesenchyme; however, in the absence of epithelium...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5289–5300.
Published: 15 November 2002
...Ying Liu; Chunqiao Liu; Yoshihiko Yamada; Chen-Ming Fan Proximal-to-distal growth of the embryonic limbs requires Fgf10 in the mesenchyme to activate Fgf8 in the apical ectodermal ridge (AER),which in turn promotes mesenchymal outgrowth. We show here that the growth arrest specific gene 1 ( Gas1...