...Steffen Lemke; Stephanie E. Busch; Dionysios A. Antonopoulos; Folker Meyer; Marc H. Domanus; Urs Schmidt-Ott The metameric organization of the insect body plan is initiated with the activation of gap genes, a set of transcription-factor-encoding genes that are zygotically expressed in broad...

...Henrique Marques-Souza; Manuel Aranda; Diethard Tautz The gap gene hunchback in Drosophila acts during syncytial blastoderm stage via a short-range gradient and concentration-dependent activation or repression of target genes. Orthologues of hunchback can be easily found in other insects...

... of expression in the procephalic neuroectoderm and in the neuroblast layer of the gap genes empty spiracles, hunchback, huckebein, sloppy paired 1 and tailless ; the homeotic gene labial ; the early eye genes dachshund, eyeless and twin of eyeless ; and several other marker genes (including castor, pdm1...

...Ze’ev Paroush; S. Mark Wainwright; David Ish-Horowicz ABSTRACT Patterning of the non-segmental termini of the Drosophila embryo depends on signalling via the Torso receptor tyrosine kinase (RTK). Activation of Torso at the poles of the embryo triggers restricted expression of the zygotic gap genes...

... abdominal-A and Abdominal-B are transcribed. There is spatially restricted transcription of the infraabdominal regions ( infraabdominal transcripts) that may reflect this specific activation. We show that the gap genes hunchback, Krüppel, tailless and knirps control abdominal-A and Abdominal-B expression...

... regulatory effects on their target genes. However, there is so far little direct in vivo evidence that a single factor can autonomously activate and repress a given target gene. We have analysed here the regulatory capabilities of the gap gene hunchback by creating an artificial gradient of hunchback...

... mutants suggests that the products of the gap genes hunchback, Krüppel, knirps and giant activate paired expression in stripes. With the exception of stripe 1, which is activated by even-skipped , and stripe 8, which depends upon runt , the primary pair-rule proteins are required for subsequent modulation...

... of Biological Chemistry, University of California, Los Angeles, California 90024, USA 13 01 1992 © 1992 by Company of Biologists 1992 maternal morphogens Drosophila pattern formation gap genes tailless terminal domains Four maternal systems of genetic information...

... and a posterior domain. Activation of the anterior domain is dependent on the maternal bicoid gradient while activation of the posterior domain requires maternal nanos gene product. Initial expression is not abolished by mutations in any of the zygotic gap genes. By cellular blastoderm, the initial pattern...

... studies show that the gt patterns overlap with protein gradients specified by the gap genes hunchback (hb) and knirps (kni) . Analysis of all known gap mutants, as well as mutations that disrupt each of the maternal organizing centers, indicate that maternal factors are responsible for initiating gt...

...Rachel Kraut; Michael Levine The gap genes play a key role in establishing pair-rule and homeotic stripes of gene expression in the Dros-ophila embryo. There is mounting evidence that overlapping gradients of gap gene expression are crucial for this process. Here we present evidence...

...Ulrike Gaul; Herbert Jäckle ABSTRACT The metameric organisation of the Drosophila embryo is generated early during development, due to the action of maternal effect and zygotic segmentation and homeotic genes. The gap genes participate in the complex process of pattern formation by providing a link...

... interactions are not sufficient, however, to explain the periodicity of the hairy and eve patterns, so we examined specific gap gene mutant combinations to uncover their regulatory effects on these two genes. Our surprising observation is that the hairy and eve genes are expressed in embryos where the three...