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1-14 of 14
Keywords: GSK3β
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Journal Articles
Journal:
Development
Development (2022) 149 (22): dev200844.
Published: 16 November 2022
...Najat Dzaki; Shufeng Bu; Samuel Song Yuan Lau; Wei Lin Yong; Fengwei Yu ABSTRACT The evolutionarily conserved Glycogen Synthase Kinase 3β (GSK3β), a negative regulator of microtubules, is crucial for neuronal polarization, growth and migration during animal development. However, it remains unknown...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2021) 148 (24): dev199866.
Published: 23 December 2021
... motor functions under physiological conditions. Because, within an whole organism, kinase cascades display considerable crosstalk and play multiple roles in cell homeostasis, deciphering which kinase(s) is/are involved in a particular process has been challenging. Previously, we found that GSK3β plays...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
.... Depletion of DDX3 decreases AKT activity and AKT-dependent inhibitory phosphorylation of GSK3β, leading to reduced levels of β-catenin and Snai1: two GSK3β substrates that are crucial for NC induction. DDX3 function in regulating these downstream signaling events during NC induction is likely mediated...
Includes: Supplementary data
Journal Articles
Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons
In collection:
Neural development
Journal:
Development
Development (2020) 147 (3): dev180232.
Published: 3 February 2020
... both neuronal polarity and axon growth. Using compartmentalised microfluidic neuronal cultures, we identified a local role for miR-26a in the axon, where the repression of local synthesis of GSK3β controls axon development and growth. Removal of this repression in the axon triggers local translation...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2018) 145 (10): dev161042.
Published: 14 May 2018
... phase and an efficient S phase, permitting the continuous proliferation of GSCs for gamete production. GSK3β Cell cycle Germ cells Stem cell proliferation National Institutes of Health 10.13039/100000002 GM98200 GM98200S1 American Cancer Society 10.13039/100000048...
Includes: Supplementary data
Journal Articles
Jörg Steinfeld, Ichie Steinfeld, Nicola Coronato, Meggi-Lee Hampel, Paul G. Layer, Masasuke Araki, Astrid Vogel-Höpker
Journal:
Development
Development (2013) 140 (24): 4959–4969.
Published: 15 December 2013
... surface ectoderm and subsequently in dorsal optic vesicle cells. Activation of Wnt signalling by implanting Wnt3a-soaked beads or inhibiting GSK3β at optic vesicle stages inhibits NR development and converts the entire optic vesicle into RPE. Surface ectoderm removal at early optic vesicle stages...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2009) 136 (17): 2987–2996.
Published: 1 September 2009
... levels of HA are required to sustain proliferation of mesenchymal cells in the regenerative bud. Pharmacological and genetic inhibition of GSK3βwas sufficient to rescue proliferation and tail regeneration when HA synthesis was blocked, suggesting that GSK3β is downstream of the HA pathway. We have...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2008) 135 (18): 3137–3148.
Published: 15 September 2008
... in zebrafish by the E(Spl) factors Her5 and Her11, but the molecular cascades cooperating with Her5/11, and those accounting for their reduced effect in the medial IZ, remain unknown. We demonstrate here that the kinases Gsk3β and cAMP-dependent protein kinase A (PKA) are novel determinants of IZ formation...
Journal Articles
Journal:
Development
Development (2007) 134 (12): 2207–2217.
Published: 15 June 2007
... ) Embryos were injected at the 32-cell stage with Vent2 RNA in anterior D1 cells or in posterior D4 cells with either Gsk3β or Gsk3β plus Vent2, followed by in situ hybridization at stage 18 with hhex , and stage 35 with for1 or pdx1 probes.( G ) These data suggest a molecular pathway in which Wnt/β...
Includes: Supplementary data
Journal Articles
Heather E. Weitzel, Michele R. Illies, Christine A. Byrum, Ronghui Xu, Athula H. Wikramanayake, Charles A. Ettensohn
Journal:
Development
Development (2004) 131 (12): 2947–2956.
Published: 15 June 2004
... endomesoderm specification. Here, we use in-vivo measurements of the half-life of fluorescently tagged β-catenin in specific blastomeres to demonstrate a gradient in β-catenin stability along the animal-vegetal axis during early cleavage. This gradient is dependent on GSK3β-mediated phosphorylation of β...
Journal Articles
Sandra van de Water, Marc van de Wetering, Jos Joore, John Esseling, Robert Bink, Hans Clevers, Danica Zivkovic
Journal:
Development
Development (2001) 128 (20): 3877–3888.
Published: 15 October 2001
...Sandra van de Water; Marc van de Wetering; Jos Joore; John Esseling; Robert Bink; Hans Clevers; Danica Zivkovic masterblind ( mbl ) is a zebrafish mutation characterised by the absence or reduction in size of the telencephalon, optic vesicles and olfactory placodes. We show that inhibition of Gsk3β...
Journal Articles
Journal:
Development
Development (2001) 128 (11): 2063–2073.
Published: 1 June 2001
... downstream of β-catenin, in order to achieve tissue-specific effects. ‡Author for correspondence (e-mail: [email protected] ) 13 3 2001 © 2001. 2001 Xenopus Wnt Xwnt-8 Lithium GSK3β β-catenin Tcf Mesoderm Signalling Embryonic organisation requires cell-to-cell...
Journal Articles
Journal:
Development
Development (2000) 127 (4): 861–868.
Published: 15 February 2000
... for dorsal development and becomes dorsally enriched shortly after cortical rotation. In mammalian cells cytoplasmic accumulation of β-catenin follows reduction of the specific activity of glycogen synthase kinase 3-beta (GSK3β). In Xenopus embryos, exogenous GSK3β suppresses dorsal development as predicted...
Journal Articles
Journal:
Development
Development (1998) 125 (13): 2489–2498.
Published: 1 July 1998
.... Significantly, the boundaries of these territories can be shifted by treatment with various reagents including zinc and lithium. We have isolated and characterized a sea urchin homolog of GSK3β/shaggy, a lithium-sensitive kinase which is a component of the Wnt pathway and known to be involved in axial...