... characterize two suppressors of memi-1(sb41) : gskl-1 and gskl-2 . Both genes encode functionally redundant sperm glycogen synthase kinase, type 3 (GSK3) protein kinases. Loss of both genes causes defects in male spermatogenesis, sperm pseudopod treadmilling and paternal-effect embryonic lethality. The two...

... , S. and Weis , W. I. ( 2000 ). Structure of the dimerization and beta-catenin-binding region of alpha-catenin . Mol. Cell   5 , 533 - 543 . 10.1016/S1097-2765(00)80447-5 Pronobis , M. I. , Rusan , N. M. and Peifer , M. ( 2015 ). A novel GSK3-regulated APC:Axin...

.... However, the regulatory mechanisms of neural progenitor homeostasis remain poorly understood. Here, we show that mammalian target of rapamycin (mTOR) is required for maintaining neural progenitor pools and plays a key role in mediating glycogen synthase kinase 3 (GSK3) signaling during brain development...

... that in Xenopus dorsal tissues FGF and Wnt signaling quell BMP signaling by degrading phosphorylated (P) Smad1/5, the BMP pathway signal transducer, via phosphorylation of the Smad1/5 linker region. We show that in zebrafish FGF/MAPK, but not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes...

...-catenin GSK3 Pluripotency Self-renewal Homeodomain-interacting protein kinase A major goal of developmental and stem cell biology is to elucidate the mechanisms that allow embryonic progenitor cells to choose a specific path for differentiation or to maintain their pluripotency...

... of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3...

... for expansion of cerebellar granule neuron precursors. The PI3K pathway stabilizes Nmyc1 protein via inhibition of GSK3-dependent Nmyc1 phosphorylation and degradation. The effects of PI3K activity on Nmyc1 stabilization are mimicked by insulin-like growth factor, a PI3K agonist with roles in central nervous...