... that Wh promotion of Mei-p26 (a human TRIM32 ortholog) function maintains ovarian germ cell homeostasis. Wh and Mei-p26 are epistatically linked, with wh and mei-p26 mutants showing nearly identical phenotypes, including germline stem cell (GSC) loss, stem-cyst formation due to incomplete cytokinesis...

..., its role in stem cells and niches has never been reported. Here, this study shows that the exocyst functions in the niche to promote germline stem cell (GSC) progeny differentiation in the Drosophila ovary by directly regulating EGFR membrane trafficking and signaling. Inactivation of exocyst...

... mediates dietary maintenance of Drosophila ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) membranes to wrap around GSCs. This wrapping may facilitate the delivery of bone morphogenetic protein stemness factors from ECs in the niche to GSCs. In addition...

...) is required for maintaining the association of escort cells (ECs) with germ cells in adult ovaries. This tight association is essential for germline stem cell (GSC) differentiation into cysts. Woc is also required in larval ovaries for the association of intermingled cells (ICs) with primordial germ cells...

... specification, resulting in aboralized embryos. Nodal and its target Gsc each rescue oral-aboral specification and patterning when expressed asymmetrically in p38-inhibited embryos. Thus, our results indicate that p38 is required for oral specification through its promotion of Nodal expression in the oral...

...M. Olivia Casanueva; Edwin L. Ferguson The available experimental data support the hypothesis that the cap cells(CpCs) at the anterior tip of the germarium form an environmental niche for germline stem cells (GSCs) of the Drosophila ovary. Each GSC undergoes an asymmetric self-renewal division...

... . 10.1242/dev.121.9.2917 We wish to thank Connie Cepko for the Soho1 probe, Jill Helms for the Cbfa1 probe and Juan Carlos Ispisua Belmonte for the Gsc probe. The β-actin GFP construct and β-actin vector were kindly provided by Jonathan Gilthorpe. The Hoxa2 was cloned by Victoria Prince...

... to the previously described goosecoid gene. The two homeodomains are 74% identical. In the first few hours of chick embryogenesis, the expression pattern of GSX is similar to GSC , in the posterior margin of the embryo and the young primitive streak. Later during gastrulation, expression of the two genes segregate...

..., overlying gsc -expressing cells in the axial hypoblast. During late gastrulation, wnt8 was no longer detected in the marginal cells at the dorsal midline and by mid-segmentation, transcripts were found in the presumptive tail bud. In contrast, wnt8b expression is spatially restricted to prospective...

... formation and hindbrain patterning. * Author for correspondence 23 08 1993 © 1993 by Company of Biologists 1993 Wnt Cwnt-8C Hox B1 gsc chick rat posterior marginal zone primitive streak rhombomere Axis formation in the chick blastula is initiated by interactions...