... cell G αq/11 signalling regulates myofibroblast function and stretch-mediated TGFβ2 signalling, which are important for alveologenesis and organ homeostasis and could be relevant to both developmental and adult lung disease. Alveologenesis TGFβ G αq/11 GPCR Lung development Cyclical...

...Vishakha Vishwakarma; Thao Phuong Le; SeYeon Chung ABSTRACT Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the cellular forces that drive cell shape changes and rearrangement. Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling...

... (GPCRs); however, the underlying mechanisms are unclear. Here, we show that a newly discovered ecdysone-responsive GPCR, ErGPCR-3, transmits the steroid hormone 20-hydroxyecdysone (20E) signal by binding 20E and promoting its entry into cells in the lepidopteran insect Helicoverpa armigera . Knockdown...

... of Biologists Ltd 2015 SUMMARY : This poster article summarises how lysophosphatidic acid is produced and metabolised during development, how it signals, and how it influences tissue and organ development. Lysophospholipid GPCR Progenitor Proliferation Differentiation Survival Migration...

... used to guide migrating cells. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 GPCR Cell migration Chemokine CXCL12 CXCR4...

... in pioneers and followers. * Author for correspondence ( [email protected] ) Competing interests statement 2 9 2010 © 2010. Axon guidance flamingo C. elegans Pioneer Follower Nervous system Cadherin Adhesion GPCR The creation of a functional...

...) Overall levels of F-actin caused by p120 ΔArm1 overexpression quantitated by pixel intensity. Scale bars: 10 μm in A; 20 μm in E-G. We next considered whether the two GPCRs could be acting as structural components of the cadherin complex, rather than signaling through G proteins. Since the ligand...

.... * Author for correspondence (e-mail: [email protected] ) 12 4 2007 © 2007. 2007 Stromal cell-derived factor-1 (SDF-1) GPCR Cell migration Axon guidance Pioneer axons Zebrafish Cell positioning and axon pathfinding are developmental processes crucial for the formation...

..., the structure of the ligand-binding domains of these GPCRs must be quite similar. Fig. 3. Inhibition of spore induction. ( A ) KP cells developing as monolayers were treated with various concentrations of GABA and glutamate, and the proportion of spores determined after 1 hour: 1 nM GABA (black...