... (GPCRs); however, the underlying mechanisms are unclear. Here, we show that a newly discovered ecdysone-responsive GPCR, ErGPCR-3, transmits the steroid hormone 20-hydroxyecdysone (20E) signal by binding 20E and promoting its entry into cells in the lepidopteran insect Helicoverpa armigera . Knockdown...

... al., 2014 ). These seven-transmembrane GPCRs bind different forms of LPA with varying affinities and activate specific heterotrimeric G protein pathways defined, in part, by Gα 12/13 , Gα q/11 , Gα i/o and Gα s . The downstream signalling cascades involve well-known mediators such as Ras, Rho, Rac...

... used to guide migrating cells. * Author for correspondence ( holger.knaut@med.nyu.edu ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 GPCR Cell migration Chemokine CXCL12 CXCR4...

... in pioneers and followers. * Author for correspondence ( hutter@sfu.ca ) Competing interests statement 2 9 2010 © 2010. Axon guidance flamingo C. elegans Pioneer Follower Nervous system Cadherin Adhesion GPCR The creation of a functional...

.... † Author for correspondence (e-mail: Christopher.Wylie@cchmc.org ) * These authors contributed equally to this work 8 5 2007 © 2007. 2007 Cortical actin Actin assembly Xenopus GPCR Cadherins C-cadherin p120 catenin Xflop LPA The Xenopus blastula is a hollow...

.... * Author for correspondence (e-mail: miyasaka@brain.riken.jp ) 12 4 2007 © 2007. 2007 Stromal cell-derived factor-1 (SDF-1) GPCR Cell migration Axon guidance Pioneer axons Zebrafish Cell positioning and axon pathfinding are developmental processes crucial for the formation...

... is not only a neurotransmitter but also an ancient intercellular signal. * Author for correspondence (e-mail: wloomis@ucsd.edu ) 7 4 2006 © 2006. 2006 gadA GrlE SDF-2 Sporulation GPCR The efficiency and timing of sporulation in Dictyostelium discoideum...