... ( Fig. 9 ) posits that canonical HH-SMO-GLI signaling in stromal cells controls expression of Tgfb2 in the stroma. Our work adds to and emphasizes the complex signaling interactions that are present in the renal stroma and cortex of the embryonic kidney, and adds to the growing body of evidence...

...Zhigang Jin; Tyler Schwend; Jia Fu; Zehua Bao; Jing Liang; Huimin Zhao; Wenyan Mei; Jing Yang Hedgehog (Hh) signaling is fundamentally important for development and adult tissue homeostasis. It is well established that in vertebrates Sufu directly binds and inhibits Gli proteins, the downstream...

... that accurately predicts tissue patterning. The analysis indicates that, for each target gene regulated by Gli, which is the transcriptional effector of Shh signalling, there is a neutral point in the gradient, either side of which altering the Gli binding affinity has opposite effects on gene expression...

...Qiang Li; Jordan P. Lewandowski; Marian B. Powell; Jacqueline L. Norrie; Seung Hee Cho; Steven A. Vokes The transcriptional response to the Hedgehog (Hh) pathway is mediated by Gli proteins, which function as context-dependent transcriptional activators or repressors. However, the mechanism...

... ). Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification . Genes Dev. 16 , 114 – 126 . Halperin-Barlev O. , Kalcheim C. ( 2011 ). Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts...

...Steven A. Marks; Daniel Kalderon Hedgehog (Hh) signaling activates full-length Ci/Gli family transcription factors and prevents Ci/Gli proteolytic processing to repressor forms. In the absence of Hh, Ci/Gli processing is initiated by direct Pka phosphorylation. Despite those fundamental...

..., to limit its expression to MPs and MFFs. We suggest a novel basis for crosstalk between the Hh and BMP pathways, whereby BMP-mediated repression of Hh target genes is promoted by a direct interaction between Smads and truncated Glis, an interaction that is abrogated by Hh induced depletion of the latter...

.... Floor plate Shh Homeodomain Nkx2.2 Pax6 Gli Morphogen A general strategy to establish cellular diversity in developing organisms is the deployment of morphogen gradients that signal at long range from localized sources to impart positional information to surrounding cells...

... and perturbs intracellular Wnt response. Nat. Genet. 39 , 1350 -1360. Guner, B. and Karlstrom, R. O. ( 2007 ). Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube. Gene Expr. Patterns 7 , 596 -605...

..., CNRS URA 2578,Pasteur Institute, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France 24 11 2008 © 2009. 2009 Retinoids Gastrulation Neurogenesis Spinal cord Somites Sonic hedgehog Gli Fibroblast growth factor Mouse In the vertebrate embryo, the trunk structures (spinal...

...., Cayuso, J., Okubo, T. and Marti, E. ( 2008 ). Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development 135 , 237 -247. Bai, C. B., Stephen, D. and Joyner, A. L. ( 2004 ). All mouse ventral spinal cord patterning by hedgehog is Gli...

... a Gli-mediated(Gli1-3) transcriptional network. Identifying Gli targets in a systematic fashion is central to the understanding of the action of Shh. We examined this issue in differentiating neural progenitors in mouse. An epitope-tagged Gli-activator protein was used to directly isolate cis-regulatory...

... of mutant alleles for Shh, Gli2 and Gli3 . Our study shows that Gli3 repressor(R) is required for patterning dorsal inner ear structures, whereas Gli activator (A) proteins are essential for ventral inner ear structures. A proper balance of Gli3R and Gli2/3A is required along the length of the dorsoventral...

.... 2007 Urinary bladder External genitalia Cloaca Internal urethra Pelvic urethra Shh (sonic hedgehog) Gli PCM (peri-cloacal mesenchyme) Smooth muscle Exstrophy Mouse During mouse development, a transient embryonic cavity called the cloaca forms at the caudal end of the hindgut...

... 7 2006 © 2006. 2006 Mammary Breast Gli Hedgehog Wnt The Hedgehog (Hh) family of secreted morphogens controls the patterning,growth, morphogenesis and homeostasis of many tissues, including vertebrate and invertebrate epidermal appendages( Ingham and McMahon, 2001 ). The Hh...

... spatiotemporal expression of Myf5 in the epaxial domain of the somite, mediating the synergistic action of the Wnt/β-catenin and the Shh/Gli pathways. Taken together, these results demonstrate that Myf5 is a direct target of Wnt/β-catenin, and that its full activation requires a cooperative interaction between...

... orthologs SPOP or LOC339745 modulate Gli levels and Hh-mediated responses, and even contribute to cancer. We thank S. Grimm for naming roadkill ; M. Scott, M. Mortin, T. Kornberg, R. Blackman, R. Johnson, P. Ingham, D. Kalderon, H. Mistry, C. Doe,and the Bloomington Stock Center for flies...

...Vân Nguyen; Ann L. Chokas; Barbara Stecca; Ariel Ruiz i Altaba The Gli proteins are critical components of multiple processes in development, homeostasis and disease, including neurogenesis and tumorigenesis. However, it is unclear how the Gli code, the sum of their combinatorial positive...

... and upstream of the Gli transcription factors,the mechanism by which IFT regulates Gli function is unknown. The developing limb provides an excellent system to study Hh signaling, in particular as it allows a biological and molecular readout of both Gli activator and repressor function. Here we report...

... Ciències Biológiques, Ed B, 4 planta, c/Dr Moliner, s/n 46100 Burjassot, València, Spain ¶ Present address: Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris Cedex 05 Paris, France 8 11 2004 ©2005. 2005 Mouse Stem cell Brain Hedgehog Gli Subventricular zone...