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Keywords: GLD-1
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Journal Articles
Journal: Development
Development (2004) 131 (19): 4831–4841.
Published: 1 October 2004
... protein GLD-1. We find that MEX-3, a second KH-domain protein, exhibits a novel, ATX-2-dependent role in preventing inappropriate translation in the germline stem cells. Together, our results suggest that ATX-2 functions in translational regulation that is mediated by GLD-1 and MEX-3 proteins. GLD-1 has...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3263–3272.
Published: 15 July 2004
.... elegans caudal homolog, pal-1 , and found that GLD-1, a member of the evolutionarily conserved STAR/Maxi-KH domain family, acts through a minimal pal-1 3′ UTR element to repress pal-1 translation in the distal germline. We also provide data suggesting that GLD-1 may repress pal-1 translation after...
Journal Articles
Journal: Development
Development (2004) 131 (1): 93–104.
Published: 1 January 2004
...Dave Hansen; Laura Wilson-Berry; Thanh Dang; Tim Schedl Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (12): 2623–2632.
Published: 15 June 2003
..., and an element that inhibits repressor activity to promote translation in the embryo. Furthermore, we show that the STAR/KH domain protein GLD-1 binds directly and specifically to the repressor element. Depletion of GLD-1 activity by RNA interference causes loss of endogenous glp-1 mRNA repression in early...