...Jinling Wu; Michael O'Donnell; Aaron D. Gitler; Peter S. Klein GIPC is a PDZ-domain-containing protein identified in vertebrate and invertebrate organisms through its interaction with a variety of binding partners including many membrane proteins. Despite the multiple reports identifying GIPC, its...

... Xenopus Frizzled Wnt Wnt1 Frizzled 3 Neural crest PDZ domain Dishevelled GIPC Wnt1 was first identified as an oncogene activated by provirus insertion ( Nusse and Varmus, 1992 ). Subsequently, Wnt1 was shown to be a member of a family of secreted glycoproteins (Wnts) that regulate cell...