... of GDNF in mouse spermatagonial stem cells blocks their differentiation and promotes self-renewal, rather than promoting their proliferation. Spermatogenesis Spermatogonial stem cells Glial cell line-derived neurotrophic factor GDNF family receptor α1 GFRα1 National Institute of Child...

... of the prostatic epithelium. However, the nature of the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are not understood. Glial cell line-derived neurotrophic factor (GDNF) binds GDNF family receptor α1 (GFRα1) and signals through activation of RET tyrosine kinase...

... deficiency blocks death of colon-derived enteric neurons induced by GDNF deprivation. This study reveals an essential role for GFRα1 in the survival of enteric neurons and suggests that caspase-independent death can be triggered by abolition of neurotrophic signals. GFRα1 GDNF Enteric neuron Mouse...

... prevents migration of enteric neuron precursors, which remain positioned at the anterior end of the gut. Phenotypes induced by injection of antisense morpholinos against both Gfra orthologs can be rescued by introduction of mRNA for gfra1a or for gfra2 , suggesting that GFRα1 and GFRα2 are functionally...