... © 2010. 2010 Sea urchin embryo Endomesoderm Nodal BMP2/4 Activin FoxA FoxD sm30 GATA1/2/3 LMO2 ese gcm Pigment cells Blastocoelar cells In vertebrates, Nodal factors play conserved roles in the induction of the mesoderm and endoderm, in the formation of a dorsally...

...Jenifer C. Croce; David R. McClay Endomesoderm is the common progenitor of endoderm and mesoderm early in the development of many animals. In the sea urchin embryo, the Delta/Notch pathway is necessary for the diversification of this tissue, as are two early transcription factors, Gcm and FoxA...

... (GCM) and GCM2 control plasmatocyte development, whereas the RUNX factor Lozenge (LZ) is required for crystal cell differentiation. We have investigated the segregation process that leads to the formation of these two cell types, and the interplay between LZ and GCM/GCM2. We show that,surprisingly, gcm...

...Yoshihiro Yuasa; Masataka Okabe; Shingo Yoshikawa; Katsuhiko Tabuchi; Wen-Cheng Xiong; Yasushi Hiromi; Hideyuki Okano In Drosophila , cell-fate determination of all neuroectoderm-derived glial cells depends on the transcription factor Glial cells missing (GCM), which serves as a binary switch...

... not affect final axonal patterning and connectivity. However, under these conditions, glial cells do not fragment but leave the epithelium by a mechanism that is reminiscent of cell competition. Finally, we present evidences showing that glial cells are committed to apoptosis independently of gcm...

...Yoshihiko Umesono; Yasushi Hiromi; Yoshiki Hotta During Drosophila neurogenesis, glial differentiation depends on the expression of glial cells missing ( gcm ). Understanding how glial fate is achieved thus requires knowledge of the temporal and spatial control mechanisms directing gcm expression...

...Marc R. Freeman; Chris Q. Doe In many organisms, single neural stem cells can generate both neurons and glia. How are these different cell types produced from a common precursor? In Drosophila , glial cells missing ( gcm ) is necessary and sufficient to induce glial development in the CNS. gcm mRNA...

... for correspondence (e-mail: [email protected] ) 19 11 1999 20 12 1999 © 2000 by Company of Biologists 2000 Glia Axon guidance Ablation gcm CNS Drosophila Axons extend to form intricate and stereotyped trajectories. Local and long-range cues are thought to aid...

... lateral glial development is controlled by the gcm gene. Subsequent glial cell differentiation depends partly on the pointed gene. Here we describe a novel component required for all CNS glia development. The tramtrack gene encodes two zinc-finger proteins, one of which, ttkp69, is expressed in all non...