... of Wnt5a in the posterior part of mouse embryos causes a local disruption of hair follicle orientation. The misoriented hair follicle phenotype in Wnt5a overexpressing mice can be rescued by a heterozygous loss of Fzd6 , suggesting Wnt5a is likely to signal through Fzd6. Although the membrane distribution...

... to the skin surface. Here, we demonstrate that the randomly oriented hair phenotype observed in frizzled 6 ( Fzd6 ) mutants results from a partial loss of the polarity, due to the functional redundancy of another closely related frizzled gene, Fzd3 . Double knockout of Fzd3 and Fzd6 globally, or only...