... shown that the transcription factor FTZ-F1 is essential for PG histolysis. We have found that FTZ-F1 depletion towards the end of the final nymphal instar downregulates the expression of E93 , whereas E93-depleted nymphs molt to adults that retain a functional PG. Interestingly, these adults are able...

...Masa-aki Yamada; Takehide Murata; Susumu Hirose; Giovanni Lavorgna; Emiko Suzuki; Hitoshi Ueda ABSTRACT FTZ-F1, a member of the nuclear receptor superfamily, has been implicated in the activation of the segmentation gene fushi tarazu during early embryogenesis of Drosophila melanogaster . We found...

...-F1, a member of the nuclear receptor superfamily. Ftz-F1 and the Fushi tarazu homeodomain bind the sites with 4-to 8-fold cooperativity, suggesting that direct contact between the two proteins may contribute to target recognition. Even parasegmental reporter expression is dependent on Fushi tarazu...

... on the molecular mechanism of fDE1-dependent regulation should provide insight on the intertwined activities of these two transcriptional regulators and their inter-actions with the FTZ-F1 family of nuclear receptors. Two nuclear factors that are likely to be important for the regulatory phenomena that we...