... ); the gap gene hunchback ( hb ); the pair-rule genes fushi tarazu ( ftz ), even- skipped ( eve ), hairy ( h ), and runt ( run ); the segment polarity genes engrailed ( en ) and wingless ( wg ) and the terminal gap genes tailless ( tll ) and huckebein ( hkb ). The expression patterns...

...-numbered parasegments. Here we report that, within an engrailed enhancer, adjacent and conserved binding sites for the Fushi tarazu protein and a cofactor are each necessary, and together sufficient, for transcriptional activation. Footprinting shows that the cofactor site can be bound specifically by Ftz...