...Yusuke Mii; Masanori Taira Secreted Frizzled-related proteins (sFRPs) are thought to negatively modulate Wnt signalling. Although Wnt proteins are thought to diffuse extracellularly and act as morphogens, little is known about the diffusibility of either Wnts or sFRPs. Here we show that Frzb...

... morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol. Cell. Biol. 25 , 3648 -3657. Lin, K., Wang, S., Julius, M. A., Kitajewski, J., Moos, M., Jr and Luyten, F. P. ( 1997 ). The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling...

... and shown to act in different ways. Xnot acts as a transcriptional repressor within the mesodermal region. Gsc acts in deeper vegetal cells, where it regulates Frzb expression to maintain Xnot expression in the neighbouring notochord territory. These results suggest that, during gastrulation, the necessary...