... of the optic nerve. Genetic evidence further supports that the formation of an Frs2α-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling in this process, whereas constitutively active Ras signaling can rescue ocular coloboma in the FGF signaling mutants. Our results thus...

... (activation) of Erk1/2 and PI3-K/Akt signaling. However, only Fgfr stimulation leads to lens fiber cell differentiation in the developing mammalian embryo. Additionally, within the lens, only Fgfrs activate the signal transduction molecule Frs2α. Loss of Frs2α in the lens significantly increases apoptosis...

... deletion of fibroblast growth factor receptor substrate 2α ( Frs2 α), a key docking protein that transmits fibroblast growth factor receptor intracellular signaling ( Frs2 α UB−/− ) leads to mild ureteric defects. Mice with point mutations in the Frs2α binding site of Fgfr2 ( Fgfr2 LR/LR ) have normal...