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Keywords: Frizzled
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Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 05 October 2020
... proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and shortened cochlea – both hallmarks of PCP defects. Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev168799.
Published: 16 December 2019
... Frizzled In metazoans, anterior-posterior (AP) axis specification and patterning is one of the first fundamental developmental processes that is crucial for establishing the correct adult body plan. Studies have shown a highly conserved role for Wnt signaling in establishing the AP axis in a number...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev174789.
Published: 09 August 2019
... Nusse , R. ( 1996 ). A new member of the frizzled family from Drosophila functions as a Wingless receptor . Nature   382 , 225 - 230 . 10.1038/382225a0 Bhanot , P. , Fish , M. , Jemison , J. A. , Nusse , R. , Nathans , J. and Cadigan , K. M. ( 1999 ). Frizzled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168294.
Published: 29 April 2019
... resulted in loss of polarized rosette structures in the aggregates. Mutation in frizzled9b reduced total kidney nephron number, caused defects in tubule morphology and reduced regeneration of new nephrons after injury. Our results demonstrate an essential role for Wnt/frizzled signaling in adult zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
...Chun-Wei He; Chien-Po Liao; Chung-Kuan Chen; Jérôme Teulière; Chun-Hao Chen; Chun-Liang Pan ABSTRACT Signaling that instructs the migration of neurons needs to be tightly regulated to ensure precise positioning of neurons and subsequent wiring of the neuronal circuits. Wnt-Frizzled signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168229.
Published: 10 December 2018
... localised within each cell. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part of a cell becomes different from another part .’       Sydney Brenner (1994) Looking at the Stan/Fz system...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169326.
Published: 03 December 2018
...Sergio Garrido-Jimenez; Angel-Carlos Roman; Alberto Alvarez-Barrientos; Jose Maria Carvajal-Gonzalez ABSTRACT In vertebrates, planar polarization of ciliary basal bodies has been associated with actin polymerization that occurs downstream of the Frizzled-planar cell polarity (Fz-PCP) pathway. In...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3399–3409.
Published: 01 September 2014
... heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse. We identify Ankyrin 2 as a target of Go signaling required for NMJ formation. Moreover, the Go-ankyrin interaction is conserved in the mammalian neurite outgrowth pathway. Without ankyrins, a major switch in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4374–4382.
Published: 01 December 2012
... asymmetric cortical actin organisation. Morpholino antisense oligonucleotide and mRNA injection studies showed that PCP development requires the Clytia orthologues of the core Fz-PCP pathway components Strabismus (CheStbm), Frizzled (CheFz1) and Dishevelled (CheDsh). Morpholinos targeting any of these...
Journal Articles
Journal: Development
Development (2011) 138 (13): 2751–2759.
Published: 01 July 2011
... Dachsous (Ds) and Frizzled (Fz) systems – play key roles in the establishment and maintenance of such polarity. There has been great progress in uncovering the how these genes work together to produce planar polarity, yet fundamental questions remain unanswered. Here, we study the Drosophila larval ventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3411–3415.
Published: 15 October 2010
... Gogh (Strabismus) Dachsous Fat Frizzled Gradients Starry night (Flamingo) Drosophila Planar cell polarity (PCP) is likely to be a property of all or most epithelial cells, even though they do not always evince it ( Lawrence et al., 2007 ). Some cells reveal their polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 745–754.
Published: 01 March 2010
...-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP. * Author for correspondence ( lshsu@life.nthu.edu.tw ) Competing interests statement 7 1 2010 © 2010. Echinoid Flamingo (Starry night) DE-cadherin (Shotgun) Frizzled Planar cell polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (12): 2121–2131.
Published: 15 June 2009
... of dscr5 disrupted Knypek membrane localization and caused an enhanced Frizzled 7 receptor endocytosis in a Caveolin-dependent manner. Furthermore, dscr5 knockdown promoted specific Dishevelled degradation by the ubiquitin-proteosome pathway. These results reveal a functional link between Knypek...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3103–3111.
Published: 15 September 2008
... localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement. Notwithstanding our evidence for post-translational regulation of Mwh activity in the normal context of the pupal wing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 367–375.
Published: 15 January 2008
... frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3055–3064.
Published: 01 September 2007
... migration. This is apparently due, in part, to a loss of regulation of Rho GTPase activity by the planar polarity receptor Frizzled,which itself becomes localised to the migratory edge of the border cells. We conclude that, during collective cell migration, the planar polarity pathway can mediate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4749–4759.
Published: 01 December 2006
... markedly with their reported role in reintegration of neuroepithelial daughter cells into the neuroepithelial layer after cell division. * Author for correspondence (e-mail: hitoshi@brain.riken.jp ) 28 9 2006 © 2006. 2006 Zebrafish frizzled celsr Facial motor neuron...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4561–4572.
Published: 15 November 2006
... other set, the Stan system, encodes Starry night (Stan or Flamingo) and Frizzled. The prevailing view is that the Ds system acts via the Stan system to orient cells. However, using the Drosophila abdomen, we find instead that the two systems operate independently: each confers and propagates polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3723–3732.
Published: 15 September 2006
... unknown. Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz)receptors (Fz1 and/or Fz6), through the canonical β-catenin pathway, in the epaxial domain of newly formed somites. We show that Myf5 activation is dramatically reduced by blocking the Wnt/β...
Journal Articles
Journal: Development
Development (2006) 133 (12): 2315–2324.
Published: 15 June 2006
... Junction Four-jointed Dachs Frizzled Grunge Atrophin As Ft and Ds are protocadherins ( Clark et al., 1995 ; Mahoney et al.,1991 ), differences in cell adhesion have been invoked to explain the mutant phenotypes. When homozygous mutant clones are generated in wild-type discs, they...
Includes: Supplementary data