... retardation protein binds staufen transcript to regulate the Coracle scaffold determining synaptic glutamate receptor accumulation, with intercellular signaling through Mothers against decapentaplegic phosphorylation driving synaptic bouton formation. FMRP Fragile X syndrome Synaptogenesis Synapse...

... ; Bassell and Warren, 2008 ; Davis and Broadie, 2017 ). Functional loss of FMRP during development leads to fragile X syndrome (FXS), an intellectual disability. Many FXS symptoms appear early in life, including increasing autism features and emerging sensory hyperarousal, anxiety and hyperactivity...

...Caleb A. Doll; Kendal Broadie The activity-dependent refinement of neural circuit connectivity during critical periods of brain development is essential for optimized behavioral performance. We hypothesize that this mechanism is defective in fragile X syndrome (FXS), the leading heritable cause...

.... USA 103 , 18160 - 18165 . Nurse P. ( 1990 ). Universal control mechanism regulating onset of M-phase . Nature 344 , 503 - 508 . O'Donnell W. T. , Warren S. T. ( 2002 ). A decade of molecular studies of fragile X syndrome . Annu. Rev. Neurosci. 25 , 315 - 338...

...Charles R. Tessier; Kendal Broadie Fragile X Syndrome (FraX) is a broad-spectrum neurological disorder with symptoms ranging from hyperexcitability to mental retardation and autism. Loss of the fragile X mental retardation 1 ( fmr1 ) gene product,the mRNA-binding translational regulator FMRP...

...Alan Lee; Wenjun Li; Kanyan Xu; Brigitte A. Bogert; Kimmy Su; Fen-Biao Gao Fragile X syndrome is caused by loss-of-function mutations in the fragile X mental retardation 1 gene. How these mutations affect neuronal development and function remains largely elusive. We generated specific point...