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1-7 of 7
Keywords: Foxn1
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Journal Articles
Journal:
Development
Development (2024) 151 (14): dev202730.
Published: 22 July 2024
... the transcription factor FOXN1 initiates transdifferentiation of fibroblasts into TEC-like cells (iTECs) that support T-cell differentiation in culture or after transplant . In this study, we have characterized iTEC programming at the cellular and molecular level in mouse to determine how it proceeds, and have...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2023) 150 (8): dev200995.
Published: 21 April 2023
...Jie Li; Lucas P. Wachsmuth; Shiyun Xiao; Brian G. Condie; Nancy R. Manley ABSTRACT The transcription factor FOXN1 is essential for fetal thymic epithelial cell (TEC) differentiation and proliferation. Postnatally, Foxn1 levels vary widely between TEC subsets, from low/undetectable in putative TEC...
Includes: Supplementary data
Journal Articles
Jie Li, Julie Gordon, Edward L. Y. Chen, Shiyun Xiao, Luying Wu, Juan Carlos Zúñiga-Pflücker, Nancy R. Manley
Journal:
Development
Development (2020) 147 (12): dev178988.
Published: 22 June 2020
.../ Summary: Medullary thymic epithelial cell lineage specification and progenitor formation in the fetal thymus require notch signaling via notch 1 receptors, whereas further differentiation requires notch 1 to be downregulated. Foxn1 Notch Lineage mTEC Thymus Notch signaling is a highly...
Includes: Supplementary data
Journal Articles
Kaitlin A. G. Reeh, Kim T. Cardenas, Virginia E. Bain, Zhijie Liu, Micheline Laurent, Nancy R. Manley, Ellen R. Richie
Journal:
Development
Development (2014) 141 (15): 2950–2958.
Published: 1 August 2014
... of Foxn1 , a transcription factor that marks the thymus-fated domain and is required for differentiation and proliferation of thymic epithelial cell (TEC) progenitors. By contrast, ectopic Tbx1 did not alter the expression pattern of Gcm2 , a transcription factor restricted to the parathyroid-fated domain...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2014) 141 (8): 1627–1637.
Published: 15 April 2014
..., diminished expression of the thymic epithelial cell (TEC)-specific transcription factor Forkhead box N1 (FOXN1) has been implicated as a component of the mechanism regulating age-related involution. The effects of upregulating FOXN1 function in the aged thymus are, however, unknown. Here, we show that forced...
Includes: Supplementary data
Journal Articles
Thomas Andl, Kyung Ahn, Alladin Kairo, Emily Y. Chu, Lara Wine-Lee, Seshamma T. Reddy, Nirvana J. Croft, Judith A. Cebra-Thomas, Daniel Metzger, Pierre Chambon, Karen M. Lyons, Yuji Mishina, John T. Seykora, E. Bryan Crenshaw, III, Sarah E. Millar
Journal:
Development
Development (2004) 131 (10): 2257–2268.
Published: 15 May 2004
... and its derivatives causes arrest of tooth morphogenesis and lack of external hair. The hair shaft and hair follicle inner root sheath (IRS) fail to differentiate, and expression of the known transcriptional regulators of follicular differentiation Msx1,Msx2, Foxn1 and Gata3 is markedly downregulated...
Journal Articles
Liang Ma, Jian Liu, Tobey Wu, Maksim Plikus, Ting-Xin Jiang, Qun Bi, Yi-Hsin Liu, Sven Müller-Röver, Heiko Peters, John P. Sundberg, Rob Maxson, Richard L. Maas, Cheng-Ming Chuong
Journal:
Development
Development (2003) 130 (2): 379–389.
Published: 15 January 2003
... regrowth and loss. During the hair cycle, Msx2 deficiency shortens anagen phase, but prolongs catagen and telogen. Msx2 -deficient hair shafts are structurally abnormal. Molecular analyses suggest a Bmp4/Bmp2/Msx2/Foxn1 acidic hair keratin pathway is involved. These structurally abnormal hairs are easily...
