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Keywords: Foxn1
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Journal Articles
Journal: Development
Development (2020) 147 (12): dev178988.
Published: 22 June 2020
.../ Summary: Medullary thymic epithelial cell lineage specification and progenitor formation in the fetal thymus require notch signaling via notch 1 receptors, whereas further differentiation requires notch 1 to be downregulated. Foxn1 Notch Lineage mTEC Thymus Notch signaling is a highly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2950–2958.
Published: 1 August 2014
... of Foxn1 , a transcription factor that marks the thymus-fated domain and is required for differentiation and proliferation of thymic epithelial cell (TEC) progenitors. By contrast, ectopic Tbx1 did not alter the expression pattern of Gcm2 , a transcription factor restricted to the parathyroid-fated domain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1627–1637.
Published: 15 April 2014
..., diminished expression of the thymic epithelial cell (TEC)-specific transcription factor Forkhead box N1 (FOXN1) has been implicated as a component of the mechanism regulating age-related involution. The effects of upregulating FOXN1 function in the aged thymus are, however, unknown. Here, we show that forced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (10): 2257–2268.
Published: 15 May 2004
... and its derivatives causes arrest of tooth morphogenesis and lack of external hair. The hair shaft and hair follicle inner root sheath (IRS) fail to differentiate, and expression of the known transcriptional regulators of follicular differentiation Msx1,Msx2, Foxn1 and Gata3 is markedly downregulated...
Journal Articles
Journal: Development
Development (2003) 130 (2): 379–389.
Published: 15 January 2003
... regrowth and loss. During the hair cycle, Msx2 deficiency shortens anagen phase, but prolongs catagen and telogen. Msx2 -deficient hair shafts are structurally abnormal. Molecular analyses suggest a Bmp4/Bmp2/Msx2/Foxn1 acidic hair keratin pathway is involved. These structurally abnormal hairs are easily...