... , but the activation of signaling pathways and transcription factors previously implicated in activation of the visceral SMC program in the ureter was unchanged. Additional gain-of-function experiments suggest that GATA6 cooperates with FOXF1 in Myocd activation and SMC differentiation, possibly as pioneer and lineage...

... Type II Collagen ( col2a1a ), Aggrecan ( acana ) and Matrilin ( matn1 and matn4 ). In foxc1a ; foxc1b and foxf1 ; foxf2a ; foxf2b mutants, the initiation of barx1 and sox9a expression in the developing arches was largely unaffected ( Fig. 5 A-C). Reciprocally, foxc1a was expressed...

... embryos is dependent upon highly conserved Forkhead and GATA transcription factor binding sites, which are bound by FOXF1 and GATA4, respectively. Furthermore, the activity of the Gata4 lateral mesoderm enhancer is attenuated by the BMP antagonist Noggin, and the enhancer is not activated in Bmp4 -null...

.... One of the genes specifically expressed in the lateral plate mesoderm, and later in its derivative, the visceral mesoderm, is the Fox gene FoxF1. Its function is critical for Xenopus gut development, and embryos injected with FoxF1 morpholino display abnormal gut development. In the absence of FoxF1...

...Margit Mahlapuu; Sven Enerbäck; Peter Carlsson The murine Foxf1 gene, encoding a forkhead – or winged helix – transcription factor, is expressed in splanchnic mesenchyme during organogenesis. The concentration of expression to subepithelial mesenchyme suggested that Foxf1 is activated by paracrine...

...Margit Mahlapuu; Mattias Ormestad; Sven Enerbäck; Peter Carlsson ABSTRACT The murine Foxf1 gene encodes a forkhead transcription factor expressed in extra-embryonic and lateral plate mesoderm and later in splanchnic mesenchyme surrounding the gut and its derivatives. We have disrupted Foxf1...