... of the Wnt/β-catenin pathway, which is required for melanocyte development, induces activation of Mitf-M, in turn repressing FoxD3 expression. In conclusion, β-catenin overexpression promotes SCP cell fate decisions towards the melanocyte lineage. 501mel and SK28 human melanoma cell lines were grown...

... of cells related by lineage rather than by cell type or function. Specification defects correlate with UNC-130:DNA binding, and UNC-130 can be functionally replaced by its human homolog, the neural crest lineage determinant FoxD3. We propose that, in contrast to terminal selectors that activate cell type...

... and the underlying mechanisms remained unknown. Analysis of progenitors expressing a Foxd3 reporter reveals that prospective melanoblasts downregulate Foxd3 and have already segregated from neural lineages before emigration. When this downregulation is prevented, late-emigrating avian precursors fail to upregulate...

... transcription factor Foxd3, which is more broadly expressed in postmitotic V1 interneurons. Our demonstration that RCs are born, and activate Oc1 and Oc2 expression, in a narrow temporal window leads us to posit that neuronal diversity in the developing spinal cord is established by the composite actions...

... earlier work demonstrated that Foxd3 is required for maintenance of NC progenitors in the embryo. Here, we show that Foxd3 mediates a fate restriction choice for multipotent NC progenitors with loss of Foxd3 biasing NC toward a mesenchymal fate. Neural derivatives of NC were lost in Foxd3 mutant mouse...

... is accounted for by a progressive ventral to dorsal relocation of neural tube progenitors prior to departure. This causes a gradual narrowing of FoxD3 , Sox9 and Snail2 expression domains in the dorsal tube that characterize the neural progenitors of the crest and these genes are no longer transcribed...

..., as the speed of CNC cells was indistinguishable from that of wild-type counterparts. We determined that the failure of CNC cells to migrate away from the neural rod correlated with the enhanced expression of two transcription factors, foxd3 and sox10 . These transcription factors have many functions in CNC...

...Brigitte L. Arduini; Kevin M. Bosse; Paul D. Henion The neural crest generates multiple cell types during embryogenesis but the mechanisms regulating neural crest cell diversification are incompletely understood. Previous studies using mutant zebrafish indicated that foxd3 and tfap2a function early...

...Aaron J. Thomas; Carol A. Erickson The first neural crest cells to emigrate from the neural tube are specified as neurons and glial cells and are subsequently followed by melanocytes of the skin. We wished to understand how this fate switch is controlled. The transcriptional repressor FOXD3...

...Lu Teng; Nathan A. Mundell; Audrey Y. Frist; Qiaohong Wang; Patricia A. Labosky Understanding the molecular mechanisms of stem cell maintenance is crucial for the ultimate goal of manipulating stem cells for the treatment of disease. Foxd3 is required early in mouse embryogenesis; Foxd3 -/- embryos...

... that FoxD3 function in the Xenopus gastrula is essential for dorsal mesodermal development and for Nodal expression in the Spemann organizer. In embryos and explants, FoxD3 induced mesodermal genes, convergent extension movements and differentiation of axial tissues. Engrailed-FoxD3, but not VP16-FoxD3...

... 28 9 2004 © 2004. 2004 Pre-placodal ectoderm Neural crest foxD3 zic2 sox2 sox3 keratin dlx5 dlx6 Cell fate determination Patterning Xenopus It was discovered over a century ago that the cranial sensory organs of vertebrates arise from discrete areas...

... conditional gain- and loss-of-function experiments using different msx1 constructs fused to a glucocorticoid receptor element to avoid an early effect of this factor. We show that msx1 expression is able to induce all other early neural crest markers tested ( snail,slug, foxd3 ) at the time of neural crest...

... to a glucocorticoid receptor element. We show that Snail is able to induce the expression of Slug and all other neural crest markers tested ( Zic5, FoxD3,Twist and Ets1 ) at the time of specification. This activation is observed in whole embryos and in animal caps, in the absence of neural plate and mesodermal...

... tube are poorly defined. In this study, we show that the winged helix transcription factor Foxd3 is expressed in both premigratory and migratory neural crest cells. Foxd3 is genetically downstream of Pax3 and is not expressed in regions of Pax3 mutant mice that lack neural crest, implying that Foxd3...

...Noriaki Sasai; Kenji Mizuseki; Yoshiki Sasai Fox factors (winged-helix transcription factors) play important roles in early embryonic patterning. We show here that FoxD3 ( Forkhead 6 ) regulates neural crest determination in Xenopus embryos. Expression of FoxD3 in the presumptive neural crest...

...Robert Kos; Mark V. Reedy; Randy L. Johnson; Carol A. Erickson The winged-helix or forkhead class of transcription factors has been shown to play important roles in cell specification and lineage segregation. We have cloned the chicken homolog of FoxD3, a member of the winged-helix class...