... or Ntn1 f/+ females to Ntn1 f/+ heterozygote males containing a Foxd1 GC allele ( Fig. 2A ) ( Kobayashi et al., 2014 ). We confirmed Ntn1 deletion by both western blot analysis of whole embryonic kidneys ( Fig. 2B ) and immunofluorescence (IF) ( Fig. 2C,D ). Importantly, no Ntn1 protein...

... and Hedgehog signals initiates and restricts foxd1 expression to the prospective temporal retina, initiating naso-temporal regionalisation of the retina. Abrogation of Foxd1 results in the loss of temporal and expansion of nasal retinal character, and consequent absence of the HAA. These structural defects...

... and interstitial cell lineages. Deletion of RBPjk, the common DNA-binding partner of all active Notch receptors, with Foxd1 tgCre results in glomerular aneurysm and perinatal death from kidney failure. This defect occurs early in glomerular development as stromal-derived, desmin-positive cells fail to coalesce...

.... Genetic deletion of the forkhead transcription factor, Foxd1, results in striking renal abnormalities, including the loss of these discrete zones and pelvic fused kidneys. We have investigated the molecular and cellular basis of the kidney phenotypes displayed by Foxd1 -null embryos and report here...

... chiasm. Ipsilaterally projecting axons arise from the ventrotemporal (VT) retina and contralaterally projecting axons primarily from the other retinal quadrants. The winged helix transcription factor Foxd1 (previously known as BF-2, Brain Factor 2) is expressed in VT retina, as well as in the ventral...