... transcription factors integrate diverse signaling outputs to specify distinct cartilages and teeth in the developing zebrafish face. Forkhead Foxc1 Foxf1 Foxf2 Sox9 Cartilage Teeth Bone Pharyngeal arches Craniofacial Zebrafish Development of the vertebrate head skeleton involves...

...; upregulation of Foxc2 favours a vascular fate, whereas higher levels of Pax3 lead to myogenesis. Foxc1 has overlapping functions with Foxc2. In Foxc1/2 double-mutant embryos, somitogenesis is severely affected, precluding analysis of somite derivatives. We have adopted a conditional approach whereby mutations...

... undifferentiated precursor cells located above the eye. Here, we demonstrate a role for Foxc1 in modulating the influence of Bmp signaling on the expression of Msx2 and the specification of these cells. Inactivation of Foxc1 results in a dramatic reduction in skull vault growth and causes an expansion of Msx2...

...Tsutomu Kume; Keyu Deng; Brigid L. M. Hogan ABSTRACT The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1 ), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1...