... for survival and progression. We show that the pioneer transcription factors Foxa1 and Foxa2 are required to regulate RNA splicing during positive selection of mouse T cells and that Foxa1 and Foxa2 have overlapping/compensatory roles. Conditional deletion of both Foxa1 and Foxa2 from DP thymocytes reduced...

... and their progenitors in mice. Like many gut endoderm derivatives, embryonic C cells were found to coexpress pioneer factors forkhead box (Fox) a1 and Foxa2 before neuroendocrine differentiation takes place. In the ultimobranchial body epithelium emerging from pharyngeal pouch endoderm in early organogenesis...

... of neurogenesis in midbrain dopamine progenitors. To elucidate direct molecular interactions between multiple regulatory factors during neuronal differentiation in mice, we characterised genome-wide binding sites of the forkhead/winged helix transcription factor Foxa1, which functions redundantly with Foxa2...

.... Here, we demonstrate a feed-forward mechanism of mDA neuron development involving Nurr1 and Foxa2. Nurr1 acts as a transcription factor for DA phenotype gene expression. However, Nurr1-mediated DA gene expression was inactivated by forming a protein complex with CoREST, and then recruiting histone...

... in the endoderm and promotes mesendodermal lineage segregation. Initially, we identified miR-335 as a regulated intronic miRNA in differentiating embryonic stem cells (ESCs). miR-335 is encoded in the mesoderm-specific transcript ( Mest ) and targets the 3′-UTRs of the endoderm-determining TFs Foxa2 and Sox17...

...Emmanouil Metzakopian; Wei Lin; Mali Salmon-Divon; Heidi Dvinge; Elisabet Andersson; Johan Ericson; Thomas Perlmann; Jeffrey A. Whitsett; Paul Bertone; Siew-Lan Ang The transcription factors Foxa1 and Foxa2 promote the specification of midbrain dopaminergic (mDA) neurons and the floor plate...

... of California, San Diego, La Jolla, CA 92093, USA 21 4 2009 © 2009. 2009 Mouse Placode Taste bud Taste papilla Mesenchyme Stem cell Progenitor cell TGF-beta SHH Wnt SOX2 FOXA2 Many vertebrate epithelia display regularly spaced specializations, such as hair follicles...

... a clear sequence of events occurring in the process of germ-layer formation, using immunohistochemistry and time-lapse confocal imaging. The T-box transcription factor brachyury (T) and the Forkhead transcription factor Foxa2 specify mesoderm and endoderm in the posterior epiblast. Fate-specified epiblast...

... Liver Pancreas Foregut Wnt β-catenin Wnt-antagonists Gsk3β Xenopus hhex foxa2 vent2 The liver and pancreas are derived from the foregut endoderm. Although we increasingly understand the genetic pathways regulating proliferation and differentiation of these organs once...

... of fatty acid synthesis) were dependent upon expression of the C/EBPα in respiratory epithelial cells. Deletion of the Cebpa gene caused increased expression of Tgfb2 , a growth factor that inhibits lung epithelial cell proliferation and differentiation. Normal expression of C/EBPα required Titf1 and Foxa2...

... an analysis of the node/notochord enhancer (NE) of Foxa2 . We first identified the core element (CE) of the enhancer, which in multimeric form drives gene expression in the node. The CE was activated in Wnt/β-catenin-treated P19 cells with a time lag, and this activation was dependent on two separate sequence...

... with androgen signaling and controls prostate differentiated response. Here, we show the mouse Foxa1 expression marks the entire embryonic urogenital sinus epithelium (UGE), contrasting with Shh and Foxa2, which are restricted to the basally located cells during prostate budding. The Foxa1-deficient mouse...

... activity in the cardiac outflow tract compared with other pharyngeal arch derivatives, including the palatal bones. Mice hypomorphic for Tbx1 failed to activate expression of the forkhead transcription factor Foxa2 in the pharyngeal mesoderm, which contains cardiac outflow precursors derived from...

...-dependent physiological interaction probably corresponds to the existence of a direct interaction between Hoxa5 and FKHR and FoxA2/HNF3β, as demonstrated by pull-down experiments achieved either in vitro or after cellular co-expression. In conclusion, we propose that the impaired growth observed...