... for survival and progression. We show that the pioneer transcription factors Foxa1 and Foxa2 are required to regulate RNA splicing during positive selection of mouse T cells and that Foxa1 and Foxa2 have overlapping/compensatory roles. Conditional deletion of both Foxa1 and Foxa2 from DP thymocytes reduced...

... there is compensatory upregulation of Grg4 . Grg3/4 double mutant mice have severe dysregulation of the pancreas gene program with ectopic expression of canonical liver genes and Foxa1 , a master regulator of the liver program. Neurod1 , an essential β cell transcription factor and predicted target of Foxa1 , becomes...

..., differential Foxa1/Foxa2 expression distinguished two spatially separated pools of C cell precursors with different growth properties. A similar expression pattern was recapitulated in medullary thyroid carcinoma cells in vivo , consistent with a growth-promoting role of Foxa1. In contrast to embryonic...

... of neurogenesis in midbrain dopamine progenitors. To elucidate direct molecular interactions between multiple regulatory factors during neuronal differentiation in mice, we characterised genome-wide binding sites of the forkhead/winged helix transcription factor Foxa1, which functions redundantly with Foxa2...

... by the transcription factor Foxa1 and that they intercalate into the outer layer of the epidermis relatively late, at the same time as embryonic hatching. Ultrastructural and molecular characterisation shows that these cells have an abundance of large apical secretory vesicles, which contain highly glycosylated...

...Gina M. Bernardo; Kristen L. Lozada; John D. Miedler; Gwyndolen Harburg; Sylvia C. Hewitt; Jonathan D. Mosley; Andrew K. Godwin; Kenneth S. Korach; Jane E. Visvader; Klaus H. Kaestner; Fadi W. Abdul-Karim; Monica M. Montano; Ruth A. Keri FOXA1, estrogen receptor α (ERα) and GATA3 independently...

...Nan Gao; Kenichiro Ishii; Janni Mirosevich; Satoru Kuwajima; Stacey R. Oppenheimer; Richard L. Roberts; Ming Jiang; Xiuping Yu; Scott B. Shappell; Richard M. Caprioli; Markus Stoffel; Simon W. Hayward; Robert J. Matusik We have previously shown that a forkhead transcription factor Foxa1 interacts...