... Ltd 2021 Summary: In the simple chordate Ciona , the notochord-specific transcription factor Brachyury acts together with Foxa.a as part of a densely interlocked FGF-dependent feed-forward network. Brachyury Ciona FoxA GRN Feedforward Notochord The notochord...

...Rebecca M. Fox; Aria Vaishnavi; Rika Maruyama; Deborah J. Andrew FoxA transcription factors play major roles in organ-specific gene expression, regulating, for example, glucagon expression in the pancreas, GLUT2 expression in the liver, and tyrosine hydroxylase expression in dopaminergic neurons...

... of dorsal-ventral polarity in the sea urchin and support the idea that the ventral ectoderm, like the Spemann organiser in vertebrates, is an organising centre that is required for patterning all three germ layers of the embryo. Sea urchin embryo Endomesoderm Nodal BMP2/4 Activin FoxA FoxD...

...Jenifer C. Croce; David R. McClay Endomesoderm is the common progenitor of endoderm and mesoderm early in the development of many animals. In the sea urchin embryo, the Delta/Notch pathway is necessary for the diversification of this tissue, as are two early transcription factors, Gcm and FoxA...

...Yale J. Passamaneck; Lavanya Katikala; Lorena Perrone; Matthew P. Dunn; Izumi Oda-Ishii; Anna Di Gregorio The notochord is a defining feature of the chordate body plan. Experiments in ascidian, frog and mouse embryos have shown that co-expression of Brachyury and FoxA class transcription factors...

... underlying asymmetric cell division. The ectoderm signal suppresses MAPK activation and expression of Hr-FoxA , which encodes an intrinsic competence factor for notochord induction, in the nerve cord lineage. Eggs of the ascidian Halocynthia roretzi were spawned under temperature and light control...

...Paola Oliveri; Katherine D. Walton; Eric H. Davidson; David R. McClay The foxa gene is an integral component of the endoderm specification subcircuit of the endomesoderm gene regulatory network in the Strongylocentrotus purpuratus embryo. Its transcripts become confined to veg2, then veg1...

... showed that this enhancer was a direct target of the Ci-FoxA-a gene, a FoxA/HNF3 orthologue expressed in anterior ectodermal and mesendodermal lineages from the eight-cell stage. Gain- and loss-of-function experiments revealed that Ci-FoxA-a is necessary and sufficient within the ectoderm to impose...

... ) * These authors contributed equally to this work 18 3 2004 © 2004. 2004 Endoderm Transcription Sox17 β-catenin Foxa Gata Xenopus In the vertebrate embryo the endoderm gives rise to the epithelial lining of the respiratory and gastrointestinal tract, as well as to the liver...