...Yiyun Zhou; Sarah E. Popadowski; Emily Deutschman; Marc S. Halfon ABSTRACT Pleiotropic signaling pathways must somehow engender specific cellular responses. In the Drosophila mesoderm, Ras pathway signaling specifies muscle founder cells from among the broader population of myoblasts. For somatic...

... visceral mesoderm (VM) of Drosophila embryos via specification of founder cells. However, only a limited number of target molecules for this pathway are described. We have investigated the role of the Lame Duck (Lmd) transcription factor in VM development in relationship to Jeb/Alk signal transduction. We...

... of myofibers (see Glossary, Box 1 ), each muscle is a single myofiber that arises by fusion of one founder cell (see Glossary, Box 1 ) with several fusion competent myoblasts (FCMs; see Glossary, Box 1 ). The founder cells and FCMs arise from the same population within the somatic mesoderm. Founder cells...

...%, and the number of small fibers is also occasionally reduced. This reduction in fiber number arises from a reduction in the number of founder cells contributing to the TDT at the early pupal stage. Given the role of cv in TGFβ signaling, we determined whether this pathway directly impacts TDT development. Indeed...

... contains the site of Wg production. By studying specification of muscle founder cells as marked by the lineage-specific transcription factor Slouch, we asked how mesodermal cells interpret the steady flow of Wg. Through the manipulation of place, time and amount of Wg signaling, we have observed...

... of individual adult founder cells during myogenesis does not depend on Notch-mediated lateral inhibition. Our results suggest a general mechanism by which multi-fibre muscles can be patterned. * Authors for correspondence (e-mail: [email protected] and [email protected] ) 20 4 2004 © 2004...

... of cerebellar interneurons from dividing progenitors in white matter . Neuron 16 , 47 – 54 . 10.1016/S0896-6273(00)80022-7 cell lineage cerebellum clonal analysis clonal growth compartment founder cell LaacZ mouse Purkinje Among all the structures of the central nervous system...

... myogenesis in other organisms. * Author for correspondence 02 07 1997 © 1997 by Company of Biologists 1997 selector gene myoblasts migration fusion differentiation founder cell Drosophila Ultrabithorax Several recent studies have provided clues to the molecular...

...Emma Rushton; Rachel Drysdale; Susan M. Abmayr; Alan M. Michelson; Michael Bate ABSTRACT We have used mutations in the newly identified gene myoblast city to investigate the founder cell hypothesis of muscle development in Drosophila melanogaster . In embryos mutant for myoblast city the fusion...