.... , et al. ( 2016 ). Formin is associated with left-right asymmetry in the pond snail and the frog . Curr. Biol.   26 , 654 - 660 . 10.1016/j.cub.2015.12.071 Freeman , G. and Lundelius , J. W. ( 1982 ). The developmental genetics of dextrality and sinistrality in the gastropod...

..., such as neuromuscular junctions. Despite the identification of numerous proteins that regulate synaptic actin and microtubule dynamics, the mechanisms of cytoskeletal control during terminal arbor formation have remained largely elusive. Here, we show that DAAM, a member of the formin family of cytoskeleton organizing...

... that the actin-binding protein filamin A (FlnA) physically interacts with the actin-nucleating protein formin 2 (Fmn2). Loss of FlnA and Fmn2 impairs proliferation, thereby generating multiple embryonic phenotypes, including microcephaly. FlnA interacts with the Wnt co-receptor Lrp6. Loss of FlnA and Fmn2...

... of unbranched F-actin is induced by several members of the formin family. Drosophila encodes six formin genes, representing six of the seven known mammalian subclasses. Knittrig, the Drosophila homolog of mammalian FHOD1, is specifically expressed in the developing central nervous system midline glia...

... mutants. The first intron of fozi-1 spans 7 kb upstream of the translation start site. ( B ) The structural motifs of FOZI-1 include a Q-rich region (amino acids 88-133), two C 2 H 2 zinc finger motifs (amino acids 177-201) and an FH2 formin homology domain (amino acids 369-732). ( C ) pNMA04, pNMA27...

...Tamás Matusek; Alexandre Djiane; Ferenc Jankovics; Damian Brunner; Marek Mlodzik; József Mihály Formins are involved in a wide range of cellular processes that require the remodeling of the actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the recently described...

.... It is not known how the regular pattern of membrane invagination and the morphology of the furrow canal is determined and whether actin filaments are important for furrow canal formation. We show that both the guanyl-nucleotide exchange factor RhoGEF2 and the formin Diaphanous (Dia) are required for furrow canal...

...Katayoun Afshar; Bridget Stuart; Steven A. Wasserman ABSTRACT The Drosophila Formin Homology (FH) protein Diaphanous has an essential role during cytokinesis. To gain insight into the function of Diaphanous during cytokinesis and explore its role in other processes, we generated embryos deficient...