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Keywords: Formaldehyde
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Journal Articles
Journal:
Development
Development (2022) 149 (10): dev200277.
Published: 19 May 2022
..., although ALDH2 is well known for its aldehyde-clearing mechanisms, we find that, in regenerating McSCs, Aldh2 activity is required to generate formate – the one-carbon (1C) building block for nucleotide biosynthesis – through formaldehyde metabolism. Consequently, we find that disrupting the 1C cycle...
Includes: Supplementary data
