... these cell types remains a mystery. We find that modular expression of Forkhead domain transcription factors (Fox proteins) in the zebrafish face arises through integration of Hh, Fgf, Bmp, Edn1 and Jagged-Notch pathways. Whereas loss of C-class Fox proteins results in reduced upper facial cartilages, loss...

...Maria L. Golson; Klaus H. Kaestner Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human...

... that other forkhead proteins with similar binding properties occupy these sites. Fig. 5. Successful prediction of FP enhancers from Foxa2 binding events in mDA progenitors. ( A-E ) E10.0-10.5 transgenic mouse embryos expressing lacZ from a minimal promoter and candidate enhancers bound by Foxa2...

..., in particular Bmp4, are crucial for vascular tube formation, that Bmp4 expression in extraembryonic tissues requires the forkhead transcription factor Foxf1 and that the role of hedgehog proteins in this process is to activate Foxf1 expression in the mesoderm. We show in the allantois that genetic disruption...

... migration Forkhead Heart development is governed by the tight coupling of morphogenesis and differentiation. In amniotes, complex heart anatomy results from a series of morphogenetic processes, including cell migration and cardiac tube looping. Heart morphogenesis is accompanied...

...-mail: [email protected] ) * Present address: Center for Stem Cell Biology, Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA 28 9 2006 © 2006. 2006 Xenopus FoxD3 Forkhead Nodal Mesoderm Transcription Formation...

.../forkhead proteins. Development 119 , 1301 -1315. Angerer, L. M., Oleksyn, D. W., Levine, A. M., Li, X., Klein, W. H. and Angerer, R. C. ( 2001 ). Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes. Development 128 , 4393 -4404. Ao...

... control epithelial proliferation and survival, which account for the importance of the stroma in colon carcinoma progression. Here, we show that targeting murine Foxf1 and Foxf2 , encoding forkhead transcription factors, has pleiotropic effects on intestinal paracrine signaling. Inactivation of both Foxf2...

... embryos is dependent upon highly conserved Forkhead and GATA transcription factor binding sites, which are bound by FOXF1 and GATA4, respectively. Furthermore, the activity of the Gata4 lateral mesoderm enhancer is attenuated by the BMP antagonist Noggin, and the enhancer is not activated in Bmp4 -null...

... for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 17 11 2004 ©2005. 2005 Preplacodal domain Otic placode Genetic network Paired Fibroblast growth factor forkhead distal-less msxC Pax proteins are key regulators...

... homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos. Proc. Natl. Acad. Sci. USA 93 , 6415 -6420. Brownell, I., Dirksen, M. and Jamrich, M. ( 2000 ). Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. Genesis 27 , 81...

.... We focus on the control of sexual dimorphism in the C. elegans gonad. We find that the forkhead transcription factor FKH-6 promotes male gonadal cell fates in XO animals. Loss-of-function fkh-6 mutant males have feminized gonads and often develop a vulva. In these mutant males, sex-specific cell...

...-mail: [email protected] ) 5 11 2003 © 2004. 2004 Lung Forkhead Transcription factor Development Inflammation Winged helix The respiratory tract is lined by a complex epithelium that mediates mucociliary clearance, host defense, fluid and electrolyte transport, and surfactant...

... , a winged-helix/forkhead domain transcription factor. Although it has been shown that FOXL2 is expressed in adult ovaries, its function during folliculogenesis is not known. Here, we show that the murine Foxl2 gene is essential for granulosa cell differentiation and ovary maintenance. In Foxl2 lacZ...

...Malin Hulander; Amy E. Kiernan; Sandra Rodrigo Blomqvist; Peter Carlsson; Emma-Johanna Samuelsson; Bengt R. Johansson; Karen P. Steel; Sven Enerbäck Mice that lack the winged helix/forkhead gene Foxi1 (also known as Fkh10 ) are deaf and display shaker/waltzer behavior, an indication of disturbed...

... otic primordia. Here, we identify a mutation in zebrafish, hearsay , which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1 , a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi1 appears to be the earliest...

...Margit Mahlapuu; Sven Enerbäck; Peter Carlsson The murine Foxf1 gene, encoding a forkhead – or winged helix – transcription factor, is expressed in splanchnic mesenchyme during organogenesis. The concentration of expression to subepithelial mesenchyme suggested that Foxf1 is activated by paracrine...

...Margit Mahlapuu; Mattias Ormestad; Sven Enerbäck; Peter Carlsson ABSTRACT The murine Foxf1 gene encodes a forkhead transcription factor expressed in extra-embryonic and lateral plate mesoderm and later in splanchnic mesenchyme surrounding the gut and its derivatives. We have disrupted Foxf1...

... types, such as hepatocytes, derived from the gut. The discovery that the rat hepatocyte transcription factor HNF3 is similar to the Drosophila forkhead gene, which plays a critical role in gut development in the fly, led us to isolate genes containing the HNF3/forkhead (HFH) domain that are expressed...

.... These genes share a highly conserved DNA-binding domain first found in the Drosophila gene, forkhead , which is required for the normal patterning of the developing gut and central nervous system in Drosophila . In adult mouse tissues, transcripts from HNF-3 αand β have been localised to the liver, intestine...