... understood. Here, we demonstrate that the co-repressor protein Sin3a is crucial for lung endoderm development. Loss of Sin3a in mouse early foregut endoderm led to a specific and profound defect in lung development with lung buds failing to undergo branching morphogenesis and progressive atrophy...

... or stomach lineages, respectively. These results indicate that GATA4 and GATA6 play essential roles in maintaining pancreas identity by regulating foregut endodermal fates. Remarkably, pancreatic anlagen derived from pDKO embryos also display a dramatic upregulation of hedgehog pathway components, which...

..., shape and position of all the facial skeletal elements, whether they are cartilage or membrane bones. 12 11 2001 © 2002. 2002 Foregut endoderm Neural crest Facial skeleton Hox genes Quail-chick chimeras Most of the head skeleton is formed by membrane and cartilage bones...

... at the normal positions in brain structure. Reduction in forebrain pattern is evident by the 12-somite stage, with most neuraxes lacking telencephalon and eyes, while forebrain expressions of the transcription factor genes GANF and BF1 , and of FGF8 , are absent or severely reduced. When the foregut endoderm...