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Keywords: Follistatin
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Journal Articles
Journal: Development
Development (2020) 147 (24): dev185827.
Published: 23 December 2020
... ) are expressed distally ( Fig. 1 E,F), whereas microphthalmia-associated transcription factor ( Mitf ) and Wnt family member 2b ( Wnt2b ; formerly Wnt13 ) are expressed proximally ( Fig. 1 G,H). We additionally report that two further genes, transforming growth factor β2 ( Tgfb2 ) and follistatin ( Fst ) are co...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev163014.
Published: 11 May 2018
... into type 1 cells (AT1s). BMP signaling is active in AT2s and TASCs, transiently declines post-PNX in association with upregulation of antagonists, and is restored during differentiation of AT2s to AT1s. In organoids, BMP4 inhibits AT2 proliferation, whereas antagonists (follistatin, noggin) promote AT2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4131–4142.
Published: 1 October 2011
... showed that a locally produced signal, the TGFβ superfamily ligand GDF11, regulates the genesis of olfactory receptor neurons by inhibiting proliferation of the immediate neuronal precursors (INPs) that give rise to them. GDF11 is antagonized by follistatin (FST), which is also produced locally. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (9): 1453–1464.
Published: 1 May 2009
... of Gdf11 restoring substantial neurogenesis. Notably, we find no evidence for a disruption of Fgf8 expression in Foxg1 -/- OE. However, we do observe both a failure of expression of follistatin ( Fst ), which encodes a secreted Gdf11 antagonist normally expressed in and around OE, and an increase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (17): 2959–2968.
Published: 1 September 2008
... a mechanism of action whereby Fgf9 indirectly inhibits Tgfβsignaling in mesenchymal fibroblasts. This model would suggest that high p-Erk1/2 cells function as a signaling intermediary that inhibits Tgfβsignaling. Known secreted inhibitors of Tgfβ signaling include follistatin (Fst), a homologue, follistatin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2905–2913.
Published: 1 August 2006
... by members of the TGFβ superfamily belonging to the BMP, GDF and activin subgroups. We show in particular that FGF8 tightly modulates follistatin expression, thus progressively restraining the inhibitory influence of activin B on RP differentiation. These regulations, together with FGF8 triggered apoptosis...
Journal Articles
Journal: Development
Development (2006) 133 (7): 1347–1357.
Published: 1 April 2006
... for correspondence (e-mail: t.whitfield@sheffield.ac.uk ) 1 2 2006 © 2006. 2006 Lamprey Zebrafish Agnathan Gnathostome Inner ear Otic vesicle Macula follistatin ptc otx Evolution Placode Hair cell Planar polarity pattern The vertebrate inner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (5): 1041–1053.
Published: 1 March 2004
... by a PDZ domain. Because HtrA1 is a secretory protein and has another functional domain with homology to follistatin, we examined whether HtrA1 functions as an antagonist of Tgfβfamily proteins. During embryo development, mouse HtrA1 was expressed in specific areas where signaling by Tgfβ family proteins...