...Ping Wu; Ting-Xin Jiang; Mingxing Lei; Chih-Kuan Chen; Shu-Man Hsieh Li; Randall B. Widelitz; Cheng-Ming Chuong ABSTRACT How dermis maintains tissue homeostasis in cyclic growth and wounding is a fundamental unsolved question. Here, we study how dermal components of feather follicles undergo...

... mice with Gdf9-Cre mice to specifically delete Kat8 in oocytes. Oocyte Kat8 deletion resulted in female infertility, with follicle development failure in the secondary and preantral follicle stages. RNA-seq analysis revealed that Kat8 deficiency in oocytes results in significant downregulation...

... E. Pierreux Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non...

...Patrick Jouandin; Christian Ghiglione; Stéphane Noselli When exposed to nutrient challenge, organisms have to adapt their physiology in order to balance reproduction with adult fitness. In mammals, ovarian follicles enter a massive growth phase during which they become highly dependent...

... approach, we have investigated further the role of β-catenin signaling in embryonic hair development. Forced epithelial stabilization of β-catenin resulted in precocious and excessive induction of hair follicles even in the absence of Eda/Edar signaling, a pathway essential for primary hair placode...

...Katherine L. Hahn; Joshua Johnson; Brian J. Beres; Sheena Howard; Jeanne Wilson-Rawls We have demonstrated that Notch genes are expressed in developing mammalian ovarian follicles. Lunatic fringe is an important regulator of Notch signaling. In this study, data are presented that demonstrate...

... follicle cells mutant for dm exhibit a profound decrease in their ability to grow and to carry out endoreplication,a modified cell cycle in which DNA replication occurs in the absence of cell division. In contrast to its dramatic effects on growth and endoreplication,dMyc is dispensable for the mitotic...

...Horacio M. Frydman; Allan C. Spradling The follicle cell monolayer that encircles each developing Drosophila oocyte contributes actively to egg development and patterning, and also represents a model stem cell-derived epithelium. We have identified mutations in the receptor-like transmembrane...

...Phillip A. Newmark; Stephanie E. Mohr; Lei Gong; Robert E. Boswell ABSTRACT Establishment of the anteroposterior and dorsoventral axes in the Drosophila egg chamber requires reciprocal signaling between the germ line and soma. Upon activation of the Drosophila EGF receptor in the posterior follicle...

... of vertebrate retroviruses. The Pol proteins are expressed in both follicle and nurse cells, but they do not accumulate at detectable levels in the oocyte. The Env proteins are expressed exclusively in the follicle cells starting at stage 9 of oogenesis, where they accumulate in the secretory apparatus...

...Jonathan Margolis; Allan Spradling ABSTRACT Throughout their lives, adult Drosophila females continuously produce oocytes, each surrounded by an epithelial monolayer of follicle cells. To characterize the somatic stem cells that give rise to ovarian follicle cells, we marked dividing cells using...

... by delaying addition of the drug until 6 h after the beginning of maturation but were not alleviated by the addition of exogenous oestrogen to the culture medium. When oocytes from SU-treated follicles were transferred to inseminated, recipient ewes and recovered 24h later, two-dimensional electrophoresis...