1-2 of 2
Keywords: Flt1
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response

In collection:
Cardiovascular development and regeneration
Zhen-Yu Wang, Armaan Mehra, Qian-Chen Wang, Savita Gupta, Agatha Ribeiro da Silva, Thomas Juan, Stefan Günther, Mario Looso, Jan Detleffsen, Didier Y. R. Stainier, Rubén Marín-Juez
Journal: Development
Development (2024) 151 (23): dev203028.
https://doi.org/10.1242/dev.203028
Published: 29 November 2024
... heart failure for several years, but with little success. Here, we investigate a different approach to augment VEGFA bioavailability: by deleting the VEGFA decoy receptor VEGFR1 (also known as FLT1), one can achieve more physiological VEGFA concentrations. We find that after cryoinjury, zebrafish flt1...
View article titled, <span class="search-highlight">flt1</span> inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
Open the PDF for <span class="search-highlight">flt1</span> inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response in another window
Includes: Supplementary data
Journal Articles

Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo

Janna Krueger, Dong Liu, Katja Scholz, Anja Zimmer, Yu Shi, Christian Klein, Arndt Siekmann, Stefan Schulte-Merker, Melissa Cudmore, Asif Ahmed, Ferdinand le Noble
Journal: Development
Development (2011) 138 (10): 2111–2120.
https://doi.org/10.1242/dev.063933
Published: 15 May 2011
... factor (VegfA). Here we present Flt1 (Vegf receptor 1) loss- and gain-of-function data in zebrafish showing that Flt1 regulates tip cell formation and arterial branching morphogenesis. Zebrafish embryos expressed soluble Flt1 (sFlt1) and membrane-bound Flt1 (mFlt1). In Tg(flt1 BAC :yfp) × Tg(kdrl:ras...
View article titled, <span class="search-highlight">Flt1</span> acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo
Open the PDF for <span class="search-highlight">Flt1</span> acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo in another window
Includes: Multimedia, Supplementary data