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Keywords: Filopodia
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Journal Articles
Journal: Development
Development (2020) 147 (1): dev185231.
Published: 9 January 2020
... cranial neural crest cells express AQP-1 mRNA and protein, implicating a biological role for water channel protein function during invasion. Differential AQP-1 levels affect neural crest cell speed and direction, as well as the length and stability of cell filopodia. Furthermore, AQP-1 enhances matrix...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (3): dev158477.
Published: 8 February 2018
... coalescence, and correlated with decreased islet cell differentiation. These studies identified novel cell behaviors contributing to islet morphogenesis, and suggest a model in which dynamic exploratory filopodia establish cell-cell contacts that subsequently promote cell clustering. For time-lapse analyses...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 281–291.
Published: 15 January 2017
... contacts and creates directionally biased geometry. Here, we demonstrate that FN is deposited as pillars between widely separated germ layers, namely the somitic mesoderm and the endoderm, in quail embryos. Alongside the FN pillars, long filopodia protrude from the basal surfaces of somite epithelial cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (3): 449–460.
Published: 1 February 2016
...Abhishek Sahasrabudhe; Ketakee Ghate; Sampada Mutalik; Ajesh Jacob; Aurnab Ghose Growth cone filopodia are actin-based mechanosensory structures that are essential for chemoreception and the generation of contractile forces necessary for directional motility. However, little is known about...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3769–3780.
Published: 1 November 2015
... of Biologists Ltd 2015 Summary: In sea urchin, miRNA-31 acts in primary mesenchyme cells to inhibit components of the gene regulatory network that promotes skeletogenesis. MicroRNA Primary mesenchyme cell Cell patterning Cell migration Filopodia Alx1 Pmar1 Snail VegfR Vegf signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 3058–3070.
Published: 1 September 2015
... to failed blood circulation. Similarly, inducible deletion of Cdc42 (Cdc42 Cad5KO ) at mid-gestation blocks angiogenic tubulogenesis. By contrast, deletion of Cdc42 in postnatal retinal vessels leads to aberrant vascular remodeling and sprouting, as well as markedly reduced filopodia formation. We find...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 665–671.
Published: 15 February 2015
... extensions found in epithelial cells of the somites in chicken embryos. These filopodia-like protrusions span the subectodermal space overlying the dorsal surface of the somites and contact the ectoderm. We show that these protrusions are actin- and tubulin-positive and require Rac1 for their formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4395–4405.
Published: 15 November 2014
.../by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. UNC-40/DCC UNC-5 UNC-6 Axon repulsion Filopodia Growth cone Caenorhabditis elegans Extracellular guidance cues are detected by receptors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 729–736.
Published: 15 February 2014
... mechanisms that disperse these morphogen signaling proteins remain controversial. Here, we review the conceptual background and evidence that establishes a fundamental and essential role for cytonemes as specialized filopodia that transport signaling proteins between signaling cells. This evidence suggests...
Journal Articles
Journal: Development
Development (2013) 140 (19): 4031–4040.
Published: 1 October 2013
...Li-Kun Phng; Fabio Stanchi; Holger Gerhardt Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2321–2333.
Published: 1 June 2013
... is vital for postnatal growth and survival, and is equally required for developmental and pathological angiogenesis, including during tumor growth. Our results demonstrate that SRF is selectively required for endothelial filopodia formation and cell contractility during sprouting angiogenesis, but seems...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 800–809.
Published: 15 February 2013
... [PtdIns(3,4,5) P 3 ] Filopodia Drosophila An epithelium is a coherent sheet of cells that functions as a barrier, separating an organism or tissue from its environment. Any wounds that arise in an epithelium must be closed rapidly and completely to maintain barrier function. Closure...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3859–3869.
Published: 15 October 2012
... form filopodia that incorporate into capillary loops. Although several molecules, such as vascular endothelial growth factor A (Vegfa), are known to induce sprouting, the mechanism that terminates this process to ensure neovessel stability is still unknown. Sphingosine-1-phosphate receptor 1 (S1P 1...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4433–4442.
Published: 15 October 2011
...Adam D. Norris; Erik A. Lundquist The UNC-6/netrin guidance cue functions in axon guidance in vertebrates and invertebrates, mediating attraction via UNC-40/DCC family receptors and repulsion via by UNC-5 family receptors. The growth cone reads guidance cues and extends lamellipodia and filopodia...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1839–1849.
Published: 1 May 2011
... Actin structure Filopodia Growth cone motility Drosophila The axon scaffold of every bilaterian central nerve cord, whether in insects or mammals, is built along two major axes: lateral connections within a segment and longitudinal connections between segments. Although a great deal...
Journal Articles
Journal: Development
Development (2009) 136 (21): 3657–3667.
Published: 1 November 2009
...-actin-rich basal filopodia that link adjacent presumptive lens and retinal epithelia function as physical tethers that coordinate invagination. The filopodia, most of which originate in the presumptive lens,form at E9.5 when presumptive lens and retinal epithelia first come into close contact, and have...
Journal Articles
Journal: Development
Development (2008) 135 (1): 53–63.
Published: 1 January 2008
... (B-B‴″, D-D‴″) undergoing DC (time elapsed intervals given in minutes). Syph RNAi-injected embryos exhibit misaligned stripes and delayed or incomplete dorsal hole closure. Scale bars: 20μm. 28 9 2007 © 2008. 2008 Unconventional myosin Myosin XV Dorsal closure Filopodia...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (11): 2137–2146.
Published: 1 June 2007
...Asha Dwivedy; Frank B. Gertler; Jeffrey Miller; Christine E. Holt; Cecile Lebrand The Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family of proteins is required for filopodia formation in growth cones and plays a crucial role in guidance cue-induced remodeling of the actin cytoskeleton...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (5): 937–947.
Published: 1 March 2006
.... To examine this hypothesis directly,expression of sema3a1 and/or nrp1a was manipulated in several ways. First, antisense knockdown of Sema3a1 induced CaP axons to branch excessively, stall and/or follow aberrant pathways. Furthermore,dynamic analysis showed they extended more lateral filopodia and often...
Journal Articles
Journal: Development
Development (2004) 131 (24): 6141–6151.
Published: 15 December 2004
..., thin filopodia (1-2 μm wide) for local contacts (<20 μm). Non-local, long distance contact (up to 100 μm) was initiated by filopodia that extended and retracted, extended and tracked, or tethered two non-neighboring cells. Intriguingly, the cell-to-cell contacts often stimulated a cell to change...
Includes: Multimedia, Supplementary data