... cranial neural crest cells express AQP-1 mRNA and protein, implicating a biological role for water channel protein function during invasion. Differential AQP-1 levels affect neural crest cell speed and direction, as well as the length and stability of cell filopodia. Furthermore, AQP-1 enhances matrix...

... coalescence, and correlated with decreased islet cell differentiation. These studies identified novel cell behaviors contributing to islet morphogenesis, and suggest a model in which dynamic exploratory filopodia establish cell-cell contacts that subsequently promote cell clustering. * Author...

... contacts and creates directionally biased geometry. Here, we demonstrate that FN is deposited as pillars between widely separated germ layers, namely the somitic mesoderm and the endoderm, in quail embryos. Alongside the FN pillars, long filopodia protrude from the basal surfaces of somite epithelial cells...

...Abhishek Sahasrabudhe; Ketakee Ghate; Sampada Mutalik; Ajesh Jacob; Aurnab Ghose Growth cone filopodia are actin-based mechanosensory structures that are essential for chemoreception and the generation of contractile forces necessary for directional motility. However, little is known about...

...., 2005 ; Lim et al., 2005 ; Iwama et al., 2007 ; Wilczynska and Bushell, 2015 ). MicroRNA Primary mesenchyme cell Cell patterning Cell migration Filopodia Alx1 Pmar1 Snail VegfR Vegf signaling Strongylocentrotus purpuratus Summary: In sea urchin, miRNA-31 acts in primary...

... to failed blood circulation. Similarly, inducible deletion of Cdc42 (Cdc42 Cad5KO ) at mid-gestation blocks angiogenic tubulogenesis. By contrast, deletion of Cdc42 in postnatal retinal vessels leads to aberrant vascular remodeling and sprouting, as well as markedly reduced filopodia formation. We find...

... extensions found in epithelial cells of the somites in chicken embryos. These filopodia-like protrusions span the subectodermal space overlying the dorsal surface of the somites and contact the ectoderm. We show that these protrusions are actin- and tubulin-positive and require Rac1 for their formation...

... ). unc-33 and unc-44 also displayed persistent filopodia that resolved into stable neurite-like structures ( supplementary material Movies 6 and 7 ), resulting in axon branching ( Fig. 3 ). Fig. 4. UNC-73, UNC-33 and UNC-44 are required for myr::unc-40 filopodial inhibition. (A,B...

... mechanisms that disperse these morphogen signaling proteins remain controversial. Here, we review the conceptual background and evidence that establishes a fundamental and essential role for cytonemes as specialized filopodia that transport signaling proteins between signaling cells. This evidence suggests...

...Li-Kun Phng; Fabio Stanchi; Holger Gerhardt Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell...

... is vital for postnatal growth and survival, and is equally required for developmental and pathological angiogenesis, including during tumor growth. Our results demonstrate that SRF is selectively required for endothelial filopodia formation and cell contractility during sprouting angiogenesis, but seems...

... dorsal closure in Drosophila . Differentiation 70 , 181 - 203 . Homem C. C. , Peifer M. ( 2009 ). Exploring the roles of diaphanous and enabled activity in shaping the balance between filopodia and lamellipodia . Mol. Biol. Cell 20 , 5138 - 5155 . Huang H. , Potter...

... form filopodia that incorporate into capillary loops. Although several molecules, such as vascular endothelial growth factor A (Vegfa), are known to induce sprouting, the mechanism that terminates this process to ensure neovessel stability is still unknown. Sphingosine-1-phosphate receptor 1 (S1P 1...

...Adam D. Norris; Erik A. Lundquist The UNC-6/netrin guidance cue functions in axon guidance in vertebrates and invertebrates, mediating attraction via UNC-40/DCC family receptors and repulsion via by UNC-5 family receptors. The growth cone reads guidance cues and extends lamellipodia and filopodia...

... Actin structure Filopodia Growth cone motility Drosophila The axon scaffold of every bilaterian central nerve cord, whether in insects or mammals, is built along two major axes: lateral connections within a segment and longitudinal connections between segments. Although a great deal...

...-actin-rich basal filopodia that link adjacent presumptive lens and retinal epithelia function as physical tethers that coordinate invagination. The filopodia, most of which originate in the presumptive lens,form at E9.5 when presumptive lens and retinal epithelia first come into close contact, and have...

.... Cell Biol. 4 , 246 -250. Berg, J. S., Powell, B. C. and Cheney, R. E. ( 2001 ). A millennial myosin census. Mol. Biol. Cell 12 , 780 -794. Bohil, A. B., Robertson, B. W. and Cheney, R. E. ( 2006 ). Myosin-X is a molecular motor that functions in filopodia formation. Proc. Natl. Acad. Sci...

...Asha Dwivedy; Frank B. Gertler; Jeffrey Miller; Christine E. Holt; Cecile Lebrand The Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family of proteins is required for filopodia formation in growth cones and plays a crucial role in guidance cue-induced remodeling of the actin cytoskeleton...

.... To examine this hypothesis directly,expression of sema3a1 and/or nrp1a was manipulated in several ways. First, antisense knockdown of Sema3a1 induced CaP axons to branch excessively, stall and/or follow aberrant pathways. Furthermore,dynamic analysis showed they extended more lateral filopodia and often...

..., thin filopodia (1-2 μm wide) for local contacts (<20 μm). Non-local, long distance contact (up to 100 μm) was initiated by filopodia that extended and retracted, extended and tracked, or tethered two non-neighboring cells. Intriguingly, the cell-to-cell contacts often stimulated a cell to change...