... recombination efficiency, we used our R26R-lox-stop-lox-eYFP ( R26R eYFP ) reporter to sort and isolate RNA from YFP + Acta2 -lineage traced fibroblasts at P7 when they are most abundant ( Fig. S3A ). Both Yap and Taz single gene KOs had reduced expression in the respective gene, and KO fibroblasts had...

...Mao Kuriki; Fuminori Sato; Hiroyuki N. Arai; Maina Sogabe; Mari Kaneko; Hiroshi Kiyonari; Koichi Kawakami; Yuki Yoshimoto; Chisa Shukunami; Atsuko Sehara-Fujisawa ABSTRACT Osteoblasts arise from bone-surrounding connective tissue containing tenocytes and fibroblasts. Lineages of these cell...

...Jakub Sumbal; Zuzana Koledova ABSTRACT Fibroblast growth factor (FGF) signaling is crucial for mammary gland development. Although multiple roles for FGF signaling in the epithelium have been described, the function of FGF signaling in mammary stroma has not been elucidated. In this study, we...

...-type keratinocytes into nipple-like epidermis. To identify candidate nipple-specific signaling factors, we compared gene expression signatures of sorted Pdgfrα-positive ventral K14-PTHrP and wild-type fibroblasts, identifying differentially expressed transcripts that are involved in WNT, HGF, TGFβ, IGF...

... the mesoderm and that neural crest makes no contribution. Furthermore, contrary to previous suggestions, larval fin mesenchyme cells do not generate the skeletogenic cells of the adult fin, but persist to form fibroblasts associated with adult fin rays. Our data demonstrate that zebrafish trunk neural crest...

...Charlotte A. Collins; Kai Kretzschmar; Fiona M. Watt Hair follicle formation depends on reciprocal epidermal-dermal interactions and occurs during skin development, but not in adult life. This suggests that the properties of dermal fibroblasts change during postnatal development. To examine...

...I. Ellis; J. Banyard; S. L. Schor ABSTRACT Previous studies have indicated that fetal skin fibroblasts display an elevated level of migratory activity compared to adult cells and that this may result from inherent differences in the production of hyaluronan (HA) by these cells. Data presented...

... neurons, Schwann cells and fibroblasts from transgenic mouse embryos in which the type 1 neurofibromatosis gene was disrupted by homologous recombination ( Brannan et al. (1994) Genes Development , 8,1019-1029). Normal fascicle formation by perineurial cells failed to occur in the absence of neurofibromin...

... , were haematologically stable with no evidence of neoplasia. Pluripotent embryonic cells, maintained on fibroblast feeder layers, were unable to colonize X-ir-radiated or genetically anaemic mice. Recipients of pluripotent cells died at the same time as salineinjected controls. © 1988 by Company...