... development. Chondrogenesis Chondrocyte hypertrophy Growth plate Sox9 Ihh PTHrP Fgfr3 The commitment of mesenchymal cells to the chondrogenic lineage is a key event in the formation of bones. With the exception of the bones in the cranial vault, parts of the jaw and the medial part...

...), are arranged in adjacent rows that form a boundary between a single row of inner hair cells and three rows of outer hair cells (OHCs). PCs are required for auditory function, as mice lacking PCs owing to a mutation in Fgfr3 are deaf. Here, using in vitro and in vivo techniques, we demonstrate that an Fgf8...

...Nigel P. Pringle; Wei-Ping Yu; Marisa Howell; Jennifer S. Colvin; David M. Ornitz; William D. Richardson The postnatal central nervous system (CNS) contains many scattered cells that express fibroblast growth factor receptor 3 transcripts ( Fgfr3 ). They first appear in the ventricular zone (VZ...

... demonstrated to be necessary for endogenous initiation of fiber cell differentiation. To test this possibility, we have generated transgenic mice with ocular expression of secreted self- dimerizing versions of FGFR1 (FR1) and FGFR3 (FR3). Expression of FR3, but not FR1, leads to an expansion of proliferating...

...S. Iseki; A. O. M. Wilkie; G. M. Morriss-Kay Fibroblast growth factor receptors (FGFRs) play major roles in skeletogenesis, and activating mutations of the human FGFR1, FGFR2 and FGFR3 genes cause premature fusion of the skull bones (craniosynostosis). We have investigated the patterns...

...Michael C. Naski; Jennifer S. Colvin; J. Douglas Coffin; David M. Ornitz ABSTRACT Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of skeletal growth and activating mutations in Fgfr3 cause achondroplasia, the most common genetic form of dwarfism in humans. Little is known about...