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1-14 of 14
Keywords: Fgfr2
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Journal Articles
In collection:
Musculoskeletal system
Lauren Bobzin, Audrey Nickle, Sebastian Ko, Michaela Ince, Aaron Huang, Arshia Bhojwani, Ryan Roberts, Amy E. Merrill
Journal:
Development
Development (2025) 152 (2): dev204264.
Published: 20 January 2025
... and expansion during postnatal brain growth. Genetic conditions caused by pathogenic variants in FGFR2 , such as Apert, Pfeiffer, and Crouzon syndromes, result in calvarial deformities due to premature suture fusion and a persistently open anterior fontanelle (AF). In this study, we investigated how Fgfr2...
Includes: Supplementary data
Journal Articles
Max Meuser, Lena Deuper, Carsten Rudat, Nurullah Aydoğdu, Hauke Thiesler, Patricia Zarnovican, Herbert Hildebrandt, Mark-Oliver Trowe, Andreas Kispert
Journal:
Development
Development (2022) 149 (1): dev200021.
Published: 12 January 2022
... progenitors of the distal ureteric bud. Urothelial development requires signaling input from surrounding mesenchymal cells, which, in turn, depend on cues from the epithelial primordium to form a layered fibro-muscular wall. Here, we have identified FGFR2 as a crucial component in this reciprocal signaling...
Includes: Supplementary data
Journal Articles
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling
Thomas Volckaert, Tingting Yuan, Jie Yuan, Eistine Boateng, Seantel Hopkins, Jin-San Zhang, Victor J. Thannickal, Reinhard Fässler, Stijn P. De Langhe
Journal:
Development
Development (2019) 146 (2): dev166454.
Published: 16 January 2019
... and Fgf10 signaling, suggesting a cytoplasmic role for Yap in epithelial lineage commitment. Lung Hippo Yap Fgfr2 Ilk Fgf10 Integrin β-Catenin Differentiation Progenitor The mammalian lung has a well-designed anatomical structure that allows for efficient gas exchange: an arborized...
Includes: Supplementary data
Journal Articles
Kelly J. Soady, Giusy Tornillo, Howard Kendrick, Valerie Meniel, Daria Olijnyk-Dallis, Joanna S. Morris, Torsten Stein, Barry A. Gusterson, Clare M. Isacke, Matthew J. Smalley
Journal:
Development
Development (2017) 144 (20): 3777–3788.
Published: 15 October 2017
... pathway to FGF stimulation. Mammary stem cells Branching morphogenesis PTPRB FGFR2 Terminal end bud gene expression Mouse Institute of Cancer Research 10.13039/501100000027 Wales Cancer Research Centre Breast Cancer Now 10.13039/100009794 Cancer...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2014) 141 (17): 3352–3362.
Published: 1 September 2014
... are not well understood. Here, we have examined the requirement of Fgfr2 in mouse mammary gland morphogenesis using a postnatal organ regeneration model. We found that tissue regeneration from basal stem cells is a multistep event, including luminal differentiation and subsequent epithelial branching...
Includes: Supplementary data
Journal Articles
Eric Röttinger, Alexandra Saudemont, Véronique Duboc, Lydia Besnardeau, David McClay, Thierry Lepage
Journal:
Development
Development (2008) 135 (2): 353–365.
Published: 15 January 2008
... ectopically throughout most of the ectoderm. Inhibition of either FGFA, FGFR1 or FGFR2 function severely affects morphogenesis of the skeleton. Furthermore,inhibition of FGFA and FGFR1 signaling dramatically delays invagination of the archenteron, prevents regionalization of the gut and abrogates formation...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2007) 134 (3): 557–565.
Published: 1 February 2007
... branching, the svs mutation dramatically reduces branching without reducing organ growth. Using a positional cloning approach, we identified the svs mutant lesion as a 491 bp insertion in the tenth intron of Fgfr2 that results in changes in the pattern of Fgfr2 alternative splicing. An engineered null...
Journal Articles
Journal:
Development
Development (2005) 132 (13): 2981–2990.
Published: 1 July 2005
...Thomas Schlake Reciprocal interactions between the dermal papilla and the hair matrix control proliferation and differentiation in the mature hair follicle. Analysis of expression suggests an important role for FGF7 and FGF10, as well as their cognate receptor FGFR2-IIIb, in these processes...
Includes: Supplementary data
Journal Articles
Kai Yu, Jingsong Xu, Zhonghao Liu, Drazen Sosic, Jiansu Shao, Eric N. Olson, Dwight A. Towler, David M. Ornitz
Journal:
Development
Development (2003) 130 (13): 3063–3074.
Published: 1 July 2003
...Kai Yu; Jingsong Xu; Zhonghao Liu; Drazen Sosic; Jiansu Shao; Eric N. Olson; Dwight A. Towler; David M. Ornitz Human craniosynostosis syndromes, resulting from activating or neomorphic mutations in fibroblast growth factor receptor 2 (FGFR2), underscore an essential role for FGFR2 signaling...
Journal Articles
Journal:
Development
Development (1999) 126 (24): 5611–5620.
Published: 15 December 1999
...S. Iseki; A. O. M. Wilkie; G. M. Morriss-Kay Fibroblast growth factor receptors (FGFRs) play major roles in skeletogenesis, and activating mutations of the human FGFR1, FGFR2 and FGFR3 genes cause premature fusion of the skull bones (craniosynostosis). We have investigated the patterns...
Journal Articles
Xiaoling Xu, Michael Weinstein, Cuiling Li, Michael Naski, Rick I. Cohen, David M. Ornitz, Philip Leder, Chuxia Deng
Journal:
Development
Development (1998) 125 (4): 753–765.
Published: 15 February 1998
...Xiaoling Xu; Michael Weinstein; Cuiling Li; Michael Naski; Rick I. Cohen; David M. Ornitz; Philip Leder; Chuxia Deng ABSTRACT FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. To explore functions...
Journal Articles
Journal:
Development
Development (1997) 124 (17): 3375–3384.
Published: 1 September 1997
...S. Iseki; A. O. M. Wilkie; J. K. Heath; T. Ishimaru; K. Eto; G. M. Morriss-Kay ABSTRACT Mutations in the human fibroblast growth factor receptor type 2 ( FGFR2 ) gene cause craniosynostosis, particularly affecting the coronal suture. We show here that, in the fetal mouse skull vault, Fgfr2...
Journal Articles
Journal:
Development
Development (1994) 120 (5): 1335–1346.
Published: 1 May 1994
... for correspondence * Authors contributed equally 31 January 1994 © 1994 by Company of Biologists 1994 msd mouse mutants mesoderm induction Brachyury ( T ) Evx1 goosecoid Fgf4 Fgf5 Fgfr1 Fgfr2 Sna H19 The morphogenetic movements of gastrulation...
Journal Articles
Journal:
Development
Development (1993) 119 (2): 353–361.
Published: 1 October 1993
...Matthew L. Poulin; Kevin M. Patrie; Mary Jane Botelho; Roy A. Tassava; Ing-Ming Chiu ABSTRACT Two closely related fibroblast growth factor receptors, FGFR1 and FGFR2, have been cloned from a newt ( Notophthalmus viridescens ) limb blastema cDNA library. Sequence analysis revealed that we have...