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Keywords: Fgf9
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Journal Articles
Journal: Development
Development (2010) 137 (2): 303–312.
Published: 15 January 2010
... of the center-to-pole expansion of testis initiation pathways downstream of Sry expression remain unclear. Here we demonstrate that FGF9 can act as a diffusible conductor for a poleward expansion of tubulogenic programs at early phases of testis differentiation. In XY genital ridge cultures of anterior, middle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1813–1821.
Published: 1 June 2009
... by the Y-encoded testis determining factor SRY and maintenance of expression of the Sox9 gene encoding the central transcription factor of Sertoli cell differentiation are key events in the mammalian sexual differentiation program. In the mouse XY gonad, SOX9 upregulates Fgf9 , which initiates a Sox9...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (1): 129–138.
Published: 1 January 2009
... to a time window of only 6 hours after the normal onset of Sry expression in XY gonads. If Sry was activated after 11.3 dpc, Sox9 activation was not maintained, resulting in ovarian development. This time window is delimited by the ability to engage the high-FGF9/low-WNT4 signaling states required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1519–1527.
Published: 15 April 2006
...Leo DiNapoli; Jordan Batchvarov; Blanche Capel In addition to its role in somatic cell development in the testis, our data have revealed a role for Fgf9 in XY germ cell survival. In Fgf9 -null mice, germ cells in the XY gonad decline in numbers after 11.5 days post coitum (dpc), while germ cell...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5051–5060.
Published: 15 December 2001
... and the retinal pigment epithelium in the eye. The molecular mechanisms that pattern neural and non-neural tissues within the neuroectoderm remain unknown. We report that FGF9 is normally expressed in the distal region of the optic vesicle that is destined to become the neural retina, suggesting a role in neural...
Journal Articles
Journal: Development
Development (2001) 128 (11): 2095–2106.
Published: 1 June 2001
... the initial lung bud. Fibroblast growth factors (FGFs) often mediate epithelial-mesenchymal interactions and mesenchymal Fgf10 is essential for epithelial branching in the developing lung. However, no FGF has been shown to regulate lung mesenchyme. In embryonic lung, Fgf9 is detected in airway epithelium...