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Keywords: Fgf3
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Journal Articles
Journal: Development
Development (2007) 134 (13): 2449–2458.
Published: 1 July 2007
..., loss of RA signaling does not affect foxi1 expression or otic competence, but instead results in delayed onset of fgf3 expression and impaired otic induction. fgf8 mutants depleted of RA signaling produce few otic cells, and these cells fail to form a vesicle, indicating that Fgf8 is the primary factor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 611–623.
Published: 1 February 2007
... that zebrafish embryos mutant for fgf3 and fgf8 do not express early EB placode markers, including foxi1 and pax2a . Mosaic analysis demonstrates that placodal cells must directly receive Fgf signals during a specific crucial period of development. Transplantation experiments and mutant analysis reveal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (16): 3717–3730.
Published: 15 August 2005
... epibranchial placodes. Mosaic analyses confirm that endoderm is the source of the neurogenic signal. Using a morpholino knockdown approach, we find that fgf3 is required for the majority of placode cells to undergo neurogenesis. Tissue transplants demonstrate that fgf3 activity is specifically required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (22): 5703–5716.
Published: 15 November 2004
...Justin Gage Crump; Lisa Maves; Nathan D. Lawson; Brant M. Weinstein; Charles B. Kimmel Fibroblast growth factor (Fgf) proteins are important regulators of pharyngeal arch development. Analyses of Fgf8 function in chick and mouse and Fgf3 function in zebrafish have demonstrated a role for Fgfs...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (17): 4201–4211.
Published: 1 September 2004
... the first molecular evidence whereby sensory organs direct the development of the associated non-sensory components, the semicircular canals, in vertebrate inner ears. The phenotypes induced by both RCAS -Fgf3 and RCAS -Fgf10 are complicated and appear to involve several developmental processes...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (17): 3989–4000.
Published: 1 September 2003
... for the activation of Fgf3 expression and the maintenance of Fgf10 and Bmp4 expression in the otic vesicle. Furthermore, loss of Six1 function alters the expression pattern of Nkx5.1 and Gata3 , indicating that Six1 is required for regional specification of the otic vesicle. Finally, our data suggest...
Journal Articles
Journal: Development
Development (2003) 130 (16): 3821–3829.
Published: 15 August 2003
... vhnf1 gives cellular competence to respond to Fgf signals in a caudal hindbrain-specific manner. * Author for correspondence (e-mail: [email protected] ) 1 5 2003 © 2003. 2003 Vhnf1 Fibroblast growth factor Fgf3 Fgf8 Zebrafish Hindbrain Valentino Krox20 Rhombomere Neural...
Journal Articles
Journal: Development
Development (2003) 130 (11): 2543–2554.
Published: 1 June 2003
..., is aberrant in that it invades the otic placode territory. foo is expressed in pharyngeal pouch endoderm and is required for pouch expression of pax8 and proper patterning of other markers in the pouch such as nkx2.3 . In foo/foo embryos, we observed a failure to maintain fgf3 expression in the pouches...
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (16): 3825–3837.
Published: 15 August 2002
... in the zebrafish hindbrain. Time-lapse analyses of zebrafish hindbrain development show that r4 forms first and hindbrain neuronal differentiation occurs first in r4. Two signaling molecules, FGF3 and FGF8, which are both expressed early in r4, are together required for the development of rhombomeres adjacent...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4153–4164.
Published: 1 November 2001
... is required for the regionalisation within the telencephalon. Finally, antisense experiments with morpholino-modified oligonucleotides suggest that zebrafish fgf3 , which is also expressed in the ANB, co-operates with fgf8 in subpallial development. ‡Author for correspondence (e-mail: [email protected]...
Journal Articles
Journal: Development
Development (2001) 128 (12): 2175–2186.
Published: 15 June 2001
... patterns of both fgf8 and fgf3 . Through gain- and loss-of-function experiments, we demonstrate that Fgf8 and Fgf3 act in vivo to induce the expression of Spry4, which in turn can inhibit activity of these growth factors. When overexpressed at low doses, Spry4 induces loss of cerebellum and reduction...