...Radma Mahmood; Paul Kiefer; Sarah Guthrie; Clive Dickson; Ivor Mason ABSTRACT FGF-3 has been implicated in the development of the hindbrain and otocyst in vertebrate embryos. Since the chicken embryo offers a favourable system in which to study the development of these structures, we have isolated...

... rhombomere-specific genes in mouse embryos homozygous for the kreisler ( kr ) mutation, in which rhombomeres 4-7 are replaced by a smooth morpho-logically unsegmented neural tube. Using molecular probes specific for Hoxb-1 (Hox-2 . 9), Hoxb-3 (Hox-2 . 7), Hoxb-4 (Hox-2 . 6), Krox-20 , or Fgf-3 ( Int-2 ), we...

...Suzanne L. Mansour; Judy M. Goddard; Mario R. Capecchi ABSTRACT We derived mice that carry a targeted insertion of a neo r gene in the int-2 ( Fgf-3 ) proto-oncogene coding sequences. The mutation was found to be recessive and mice that were homozygous for the insertion did not often survive...