..., as early colonization of fetal liver by immature HSCs precedes that of HSCs. Moreover, organ culture experiments show that immature HSCs acquire, in this environment, the features of HSCs. References Bertrand J. Y. , Giroux S. , Golub R. , Klaine M. , Jalil A. , Boucontet...

..., these embryos are severely anemic and die before E12. c-Myc-deficient embryos exhibit fetal liver hypoplasia,apoptosis of erythrocyte precursors and functionally defective definitive hematopoietic stem/progenitor cells. Specific deletion of c-myc flox in hemogenic or hepatocytic lineages validate...

... investigated the temporal expression of Mpl during mouse development by in situ hybridization. We found Mpl expression in the HSCs clusters emerging in the AGM region, and in the fetal liver (FL) as early as E10.5. Using Mpl -/- mice, the functional relevance of Mpl expression was tested by comparing...

... of cholangiocyte marker-positive fetal liver epithelial cells (CMP-FLEC). Differentiation potential was evaluated by injecting cell isolates from dipeptidyl peptidase IV (DPPIV) positive (DPPIV+) Fischer donor rats into the spleen of partially hepatectomized, DPPIV negative (DPPIV-)Fischer host rats exposed...

...-over, the pattern of hybridization reveals co-expression of both genes within the same cells. Even in the fetal liver, which supersedes the yolk sac as the major site of murine fetal erythropoiesis, there is a brief co-expression of ζ and α genes followed by the exclusive expression of the adult α...

...-forming cells in the rat fetal spleen and reported that they are less sensitive than fetal liver cells to excess corticosteroid in vivo ( Nagel and Nagel, 1987 ). Thus, the spleen and hepatic CFUe of the fetal rat react differently to corticosteroids. This may be because they contain different cell...

...Osamu Ohneda; Nobuaki Yanai; Masuo Obinata ABSTRACT Mouse stromal cell lines (FLS lines), established from the livers of 13-day gestation mouse fetus, supported the proliferation and differentiation of the erythroid progenitor cells from mouse fetal livers and bone marrow in a semisolid medium...