... structures, including crypt-villus architecture and smooth muscle layers that resemble native human intestine. Although the endpoint of HIO engraftment has been well described, here we aim to elucidate the developmental stages of HIO engraftment and establish whether it parallels fetal human intestinal...

... trimester of the human fetal development ( Rankin et al., 2016 ; Ernst et al., 2019 ). The esophagus is specified on the dorsal side of the common gut tube, with the lung being specified on the ventral side ( Kuwahara et al., 2020 ). At this early time, the esophagus is organized as a pseudostratified...

... describe a new workflow for isolating and expanding significant amounts of T cells from fetal human skin. Using multiparametric flow cytometry and in situ immunofluorescence, we found a large population with a naive phenotype and small populations with a memory and regulatory phenotype. Their molecular...

... and interrogate the complex network of signaling pathways and cellular transitions. Branching Fetal Human Kidney Single cell The development of the embryonic kidney is a paradigm for the complex inductive and regulatory mechanisms driving organogenesis ( Grobstein, 1953 ). In mammals...

..., we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects...

...Pätvi J. Miettine; Kristiina Heikinheimo Transforming growth factor-alpha (TGF- α ) mRNA is expressed in several pancreatic cancer cell lines, but its expression during normal fetal pancreas development has not been studied. We investigated the expression of TGF- α , its receptor (EGF-R...

...T. Kuopio; J. Tapanainen; L. J. Pelliniemi; I. Huhtaniemi ABSTRACT Fetal Leydig cells were studied in rats during and after the perinatal-neonatal period by comparing changes in morphology, number and volume with changes in testicular steroids and serum luteinizing hormone (LH) concentration...

...J. B. Kerr; C. M. Knell The ultrastructure and developmental fate of the fetal generation of Leydig cells of the rat testis was studied from the 17th day of fetal life up to 100 days after birth. The number of fetal Leydig cells per testis was determined by light microscopic morphometric analysis...

.... There is no obvious difference in the ultrastructure of germ cells in decapitated animals, their normal littermates and control animals. Therefore germ cell development in the pig is likely to be insensitive to gonadotropins during the fetal period. The development of pig germ cells follows closely the pattern...