...Naoko Yoshida; Manami Amanai; Tomoyuki Fukui; Eriko Kajikawa; Manjula Brahmajosyula; Akiko Iwahori; Yoshikazu Nakano; Shisako Shoji; Joachim Diebold; Harald Hessel; Ralf Huss; Anthony C. F. Perry Mammalian metaphase II (mII) exit and embryogenesis are induced at fertilisation by a signal thought...

...Christopher M. Saunders; Mark G. Larman; John Parrington; Llewellyn J. Cox; Jillian Royse; Lynda M. Blayney; Karl Swann; F. Anthony Lai Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca 2+ oscillations that are essential for embryo development. The mechanism...

... to environmental information, although the factor(s) that would trigger such a decision remain unknown. e-mail: [email protected] 16 11 2001 © 2002. 2002 Mouse Embryo Polarity Axis Cleavage Fertilisation Sperm The genesis of polarity * in the early embryo is crucial...

...Mark Levasseur; Alex McDougall ABSTRACT The generation of calcium oscillations at fertilisation and during mitosis appears to be controlled by the cell cycle machinery. For example, the calcium oscillations in oocytes and embryos occur during metaphase and terminate upon entry into interphase. Here...

...Orla M. McGuinness; Roger B. Moreton; Martin H. Johnson; Michael J. Berridge ABSTRACT On fertilisation of mouse oocytes, the fusing spermatozoon triggers a series of repetitive calcium (Ca 2+ ) spikes. These Ca 2+ spikes seem to be necessary for successful progression through the cell cycle...

... , the sperm normally enters the egg in an invariant position. We have found that causing fertilisation to occur in the abnormal end of the egg completely reverses the orientation of the anteroposterior axis, but gives otherwise normal development. This result suggests that a component of the sperm normally...

...Timothy R. Cheek; Orla M. McGuinness; Caroline Vincent; Roger B. Moreton; Michael J. Berridge; Martin H. Johnson ABSTRACT Exposure of freshly ovulated mouse oocytes to a fertilising spermatozoon, thimerosal, Sr 2+ or acetylcholine induced similar Ca 2+ spiking responses. We propose that each...