... demonstrate that RTCB in oocytes is required for female fertility in mice. To further test our hypothesis, we overexpressed continuously activated CDK1 (CDK1 T14A,Y15F ) in wild-type and Rtcb -null oocytes at the germinal vesicle (GV) stage ( Fig. 6 F). The GVBD rate of Rtcb -null oocytes...

... , Cenpa and Lsm14b – that potentially caused abnormal spindle organization . Collectively, our findings provide the first report elucidating the ESRP1-mediated AS program of maternal mRNA transcripts, which may contribute to oocyte meiosis and female fertility in mice. Fig. 1. Germline deletion...

... differentiation and development. KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3). Here, we report that Kdm4a as a maternal factor plays a key role in embryo survival and is vital for female fertility. Kdm4a...

.... ( 2009 ). MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility . Science   324 , 938 - 941 . 10.1126/science.1171396 Helmke , K. J. and Heald , R. ( 2014 ). TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts . J. Cell Biol...

... a novel and crucial role for basonuclin in female fertility, because developmental competence is markedly compromised in basonuclin-deficient oocytes. This phenotype is unlikely to be due to the transgenic RNAi approach used to inhibit basonuclin specifically in oocytes,because several transgenic lines...

... of development. These mice represent a specific model of disruption of the earliest stages of embryogenesis, implicating Zfp36l2, a probable mRNA-binding and destabilizing protein, in the physiological control of female fertility at the level of early embryonic development. This newly identified biological role...