... it completes a novel auto-regulatory loop that modulates BMP activity. * Author for correspondence ( [email protected] ) Competing interests statement 22 11 2010 © 2011. BMP signaling DPP LTL Feedback Imaginal disc Morphogen Throughout multicellular...

... oogenesis, the two-domain expression pattern of Broad, a transcription factor essential for the formation of the two respiratory eggshell appendages, is established by a single gradient of EGFR activation that induces both Broad and Pointed, which mediates repression of Broad. Two negative-feedback loops...

... between proneural proteins and Sina. As phyl is a direct transcriptional target of Ac and Sc, our data suggest that, in addition to mediating cell cycle arrest, proneural protein initiates a negative-feedback regulation to time the mitotic entry of neural precursors. Senseless (Sens) is expressed in all...

... this response show surprisingly normal early development. The identification of Hh-interacting protein 1 (Hhip1), a vertebrate-specific feedback antagonist of Hh signaling, raises the possibility of overlapping feedback controls. We addressed the significance of feedback systems in sonic hedgehog(Shh)-dependent...